Transcriptional regulation of hematopoiesis in Drosophila
Transcriptional regulation of hematopoiesis in Drosophila
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DOI：
10.1016/s1079-9796(03)00028-7
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发表时间：
2003-03-01
影响因子：
2.3
通讯作者：
Banerjee, U
中科院分区：
文献类型：
--
作者：
Evans, CJ;Banerjee, U
就像哺乳动物一样。果蝇中的血细胞来源于常见的多能造血前体群体。在胚胎中，这些前体来自头部中胚层，而幼虫的造血前体则存在于一个称为淋巴腺的专门器官中。造血分化位置的这种变化让人想起哺乳动物发育过程中发生的类似事件。最近的分析已经确定了几个转录调节果蝇影响造血谱系的承诺。很有趣。这些因子中的许多与指导哺乳动物造血分化的因子相似。虽然果蝇血细胞在特定谱系方面的差异要小得多，但似乎决定造血细胞命运的许多机制方面在果蝇和哺乳动物之间是保守的。在这里，我们描述了果蝇血细胞类型，它们的物理起源。以及控制这一过程的转录调节因子。(C)2003 Elsevier Science（美国）。All rights reserved.
As in mammals. blood cells in Drosophila are derived from a common multipotent hematopoietic precursor population. In the embryo, these precursors are derived from the head mesoderm, whereas larval hematopoietic precursors are found in a specialized organ called the lymph gland. This shift in location of hematopoietic differentiation is reminiscent of similar events that occur during mammalian development. Recent analysis has identified several transcriptional regulators in Drosophila that influence hematopoietic lineage commitment. Interestingly. many of these factors are similar to factors directing mammalian hematopoietic differentiation. Although Drosophila blood cells are much less varied in terms of specific lineages, it would appear that many mechanistic aspects by which hematopoietic cell fate is determined have been conserved between Drosophila and mammals. Herein, we describe the Drosophila blood cell types, their physical origin. and the transcriptional regulators that govern this process. (C) 2003 Elsevier Science (USA). All rights reserved.