Discrimination of Isomers of Dichlorobenzene Using Charge Inversion Mass Spectrometry
Discrimination of Isomers of Dichlorobenzene Using Charge Inversion Mass Spectrometry
复制标题
使用电荷反转质谱法区分二氯苯异构体
DOI：
10.5702/massspec.49.219
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
N. Morishita
中科院分区：
文献类型：
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作者：
S. Hayakawa;Kazunari Taguchi;Rie Kotani;K. Arakawa;N. Morishita
氯代芳香族化合物是众所周知的环境污染物，它们的毒性通常显著地取决于同源基团内的氯取代模式。对二恶英等剧毒环境污染物的分析需要高灵敏度，通常在万亿分之一（ppt）范围内。质谱法（MS）是最灵敏的分析方法，已用于污染物分析，但传统的质谱法无法单独用于这些有毒化学物质的异构体特定分析。在这项工作中，我们研究了可能性之间的异构体前体的氯代芳香族化合物的电荷反转质谱使用MS/MS仪器进行区分。使用Cs，K，和Na目标的电荷反转质谱测定C6 H4 Cl 2+离子产生的邻，Meta，对二氯苯（C6 H4 Cl 2）的异构体。发现电荷反转质谱显示出对所使用的每个目标的同分异构体前体的性质的明确依赖性。在目前的工作中，使用电荷反转质谱实现的二氯苯的异构体之间的清晰的歧视表明，大多数的C6 H4 Cl 2+离子通过电子碰撞获得保留的母体分子的结构，证明了这种技术的潜在效用异构体选择性微量分析的各种污染物。
Chlorinated aromatic compounds are well-known environmental pollutants and their toxicity often depends dramatically on the chlorine substitution pattern within a homological group. Analysis of extremely toxic environmental pollutants such as dioxins requires high sensitivity, typically in the parts-per-trillion (ppt) range. Mass spectrometry (MS), being the most sensitive of analytical methods, has been used for pollutant analysis, but conventional mass spectrometry alone cannot be used for isomer-specific analysis of these toxic chemicals. In this work, we investigated the possibility of discriminating among the isomeric precursors of chlorinated aromatic compounds by charge inversion mass spectrometry using an MS/MS instrument. Charge inversion mass spectra using Cs, K, and Na targets were measured for C6H4Cl2+ ions produced from the ortho-, meta-, and para-isomers of dichlorobenzene (C6H4Cl2). The charge inversion mass spectra were found to display a clear dependence on the nature of the isomeric precursors for each of the targets used. The clear discrimination among the isomers of dichlorobenzene achieved using charge inversion mass spectrometry in the present work indicates that most of the C6H4Cl2+ ions obtained by electron impact retain the structure of the parent molecules, demonstrating the potential utility of this technique for isomer-selective microanalysis of various pollutants.