Imaging the Distribution of Magnetic Nanoparticles on Animal Bodies Using Scanning SQUID Biosusceptometry Attached With a Video Camera
Imaging the Distribution of Magnetic Nanoparticles on Animal Bodies Using Scanning SQUID Biosusceptometry Attached With a Video Camera
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DOI：
10.1109/tasc.2012.2229778
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发表时间：
2013-06-01
影响因子：
1.8
通讯作者：
Wu, C. C.
中科院分区：
文献类型：
--
作者：
Chieh, J. J.;Horng, H. E.;Wu, C. C.
为了在动物身体上成像磁性纳米颗粒（MNP），医生通常在术前分析期间使用磁共振成像来确定MNP的超顺磁性特征。然而，磁共振成像是不适合其他生物医学应用，如治愈性手术切除肿瘤或药代动力学研究的MNP，因为非金属环境的要求和频繁检查的高财务成本，分别。因此，研究人员提出了其他的荧光成像技术，如荧光，使用多模态MNP与荧光指示剂。基于MNP的其他磁性特征的磁性仪器的开发避免了多模态MNP的缺点，包括生物安全风险。基于MNP的交流磁化率，先前的研究已经证明了扫描超导量子干涉器件生物阻抗测量（SSB）的磁性检查。本研究使用低噪声电荷耦合器件型摄像机，报告了SSB和电荷耦合器件的集成，以立即成像动物身体或有机组织上的磁信号。SSB的这种实时成像增加了MNP在更多临床应用中的有用性，包括成像引导的肿瘤根治性手术切除。
To image magnetic nanoparticles (MNPs) on animal bodies, physicians often use magnetic resonance imaging to determine the superparamagnetic characteristics of MNPs during preoperative analysis. However, magnetic resonance imaging is unsuitable for other biomedical applications, such as the curative surgical resection of tumors or pharmacokinetic studies of MNPs, because of the requirement of nonmetal environments and high financial cost of frequent examination, respectively. Thus, researchers have proposed other nonmagnetic imaging technologies, such as fluorescence, using multimodal MNPs with nonmagnetic indicators. The development of a magnetic instrument based on the other magnetic characteristics of MNPs avoids the disadvantages of multimodal MNPs, including the biosafety risk. On the basis of the alternating current susceptibility of MNPs, previous research has demonstrated the magnetic examination of scanning superconducting-quantum-interference-device biosusceptometry (SSB). This study, using a low-noise charge-coupled-device type of a video camera, reports the integration of SSB and charge-coupled-device to immediately image the magnetic signals on animal bodies or organic tissue. This real-time imaging by SSB increases the usefulness of MNPs for more clinical applications, including the imaging-guided curative surgical resection of tumors.