Sputum eosinophilia in chronic bronchitis and asthma.
Sputum eosinophilia in chronic bronchitis and asthma.
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慢性支气管炎和哮喘的痰液嗜酸性粒细胞增多。
DOI：
10.1159/000193861
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
A. H. Campbell
中科院分区：
文献类型：
--
作者：
J. O'Connell;L. I. Baird;A. H. Campbell
对115例慢性支气管炎和哮喘患者的痰嗜酸性粒细胞增多症的发生情况进行了调查。临床分为四组：单纯哮喘组、哮喘病程等于或大于慢性支气管炎组、慢性支气管炎近期合并哮喘组和单纯慢性支气管炎组。虽然痰嗜酸性粒细胞增多在哮喘组中更为常见，但两组间的痰嗜酸性粒细胞增多程度并无显着差异。当根据乙酰甲胆碱和异丙肾上腺素的反应(哮喘亚组，对异丙肾上腺素的反应大于或等于20%或对乙酰甲胆碱的反应大于或等于40%；慢性支气管炎亚组，对异丙肾上腺素的反应小于10%+对乙酰甲胆碱的反应小于20%)进行细分时，两组之间在痰嗜酸性粒细胞增多症的程度上有显著差异。但慢性支气管炎患者仍有痰嗜酸性粒细胞增多。在哮喘患者中，皮试阳性或服用类固醇药物的患者与皮试阴性或未服用类固醇的患者相比，痰中嗜酸性粒细胞增多的程度似乎没有差异。
The occurrence of sputum eosinophilia was investigated in 115 patients with chronic bronchitis and asthma. They were clinically divided into four groups; those with asthma only, those with asthma of equal or greater duration than chronic bronchitis, those with chronic bronchitis recently complicated by asthma and those with chronic bronchitis only. Although sputum eosinophilia was more common in the asthmatic groups there was no significant difference between the groups in the degree of sputum eosinophilia. When the groups were subdivided on the basis of methacholine and isoprenaline response (asthma subgroup, greater than or equal to 20% response to isoprenaline or greater than or equal to 40% response to methacholine; chronic-bronchitis subgroup, less than 10% response to isoprenaline plus less than 20% response to methacholine), there was a significant difference between the groups in the degree of sputum eosinophilia. However, sputum eosinophilia still occurred in the chronic bronchitics. In the asthmatic patients, there appeared to be no difference in the degree of sputum eosinophilia in those with positive skin tests, or on steroid medication, compared with those with negative skin tests or not on steroids.¿