Mouse skin tumor promoting activity of orange peel oil and d-limonene: a re-evaluation.
Mouse skin tumor promoting activity of orange peel oil and d-limonene: a re-evaluation.
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橙皮油和 d-柠檬烯的小鼠皮肤肿瘤促进活性：重新评估。
DOI：
10.1093/carcin/7.12.2047
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发表时间：
1986
期刊：
影响因子：
4.7
通讯作者：
Gould,MN
中科院分区：
文献类型：
--
作者：
Elegbede,JA;Maltzman,TH;Verma,AK;Tanner,MA;Elson,CE;Gould,MN
橙皮油先前已被证明是小鼠皮肤肿瘤的促进剂。人们一直认为这种活性是由于其主要成分（95%）d-柠檬烯。我们在两阶段皮肤癌变模型中测试了橙皮油和纯化d-柠檬烯作为皮肤肿瘤促进剂，其中肿瘤是由7,12 -二甲基苯[a]-蒽引发的。我们证实，局部应用橙皮油是一个非常弱的促进两个皮肤乳头状瘤和癌。然而，这种促进活动不能由局部应用d-柠檬烯来解释。因此，我们认为橙皮油的一种或多种次要成分具有促进作用。通过饮食给药时，橘子皮油和d-柠檬烯都没有促进作用。
Orange peel oil has previously been shown to be a promoter of mouse skin tumors. It has been assumed that this activity is due to its major (95%) constituent, d-limonene. We have tested both orange peel oil and purified d-limonene as skin tumor promoters in a two-stage skin carcinogenesis model in which tumors were initiated with 7, 12-dimethylbenz[a]-anthracene. We confirmed that topically applied orange peel oil is a very weak promoter of both skin papillomas and carcinomas. However, this promotional activity could not be accounted for by topically applied d-limonene. We thus feel that one or more minor components of orange peel oil has promotional activity. Neither orange peel oil nor d-limonene had promotional activity when given via the diet.