Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex-mediated acute lupus glomerulonephritis.
Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex-mediated acute lupus glomerulonephritis.
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DOI：
10.1084/jem.20130731
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发表时间：
2013-10-21
期刊：
影响因子：
--
通讯作者：
Fu SM
中科院分区：
文献类型：
--
作者：
Ge Y;Jiang C;Sung SS;Bagavant H;Dai C;Wang H;Kannapell CC;Cathro HP;Gaskin F;Fu SM
急性和慢性肾小球肾炎的调节机制依赖于不同的遗传机制，其中Cgnz1等位基因在免疫复合物介导的增殖性狼疮性肾炎中具有肾脏保护作用。小鼠1号染色体远端Cgnz1和Agnz1与慢性肾小球肾炎（cGN）和急性肾小球肾炎（aGN）相关。NZM2328。Lc1R27 （R27）是由Cgnz1所在的C57L/J区渗入到NZM2328而产生的。R27雌性小鼠发生由免疫复合物（IC）沉积和补体活化介导的aGN，未进展为严重蛋白尿的cGN。15个月大的R27小鼠未见终末期肾病（ESRD）。因此，aGN和cGN受单独的遗传控制，ic介导的增殖性GN不需要发展为cGN和ESRD。NZM2328和R27雌性小鼠具有相似的免疫和炎症参数。与NZM2328相比，R27小鼠对羊抗小鼠GBM血清性肾炎有抗性，支持aGN是由自身免疫介导的，而对cGN发展的抵抗是由终末器官对损伤的抵抗介导的。因此，应将自身免疫与终末器官损伤区分开来。Cgnz1区域被定位为1.34 MB的区域，包含45个基因。共鉴定出9个候选基因。这些观察结果的临床相关性得到病例研究的支持。临床意义和意义的人狼疮和其他疾病提出。
The mechanisms regulating acute and chronic glomerulonephritis are dependent on different genetic mechanisms, where the Cgnz1 allele confers kidney protection in immune complex–mediated proliferative lupus nephritis. Cgnz1 and Agnz1 on the distal region of mouse chromosome 1 are associated with chronic glomerulonephritis (cGN) and acute GN (aGN). NZM2328.Lc1R27 (R27) was generated by introgressing a C57L/J region where Cgnz1 is located to NZM2328. R27 female mice developed aGN mediated by immune complex (IC) deposition and complement activation without progression to cGN with severe proteinuria. End stage renal disease (ESRD) was not seen in R27 mice as old as 15 mo. Thus, aGN and cGN are under separate genetic control, and IC-mediated proliferative GN need not progress to cGN and ESRD. NZM2328 and R27 female mice have comparable immune and inflammatory parameters. In contrast to NZM2328, R27 mice were resistant to sheep anti–mouse GBM serum-induced nephritis, supporting the hypothesis that aGN is mediated by autoimmunity and resistance to the development of cGN is mediated by end organ resistance to damage. Thus, autoimmunity should be considered distinct from end organ damage. The Cgnz1 region has been mapped to a 1.34 MB region with 45 genes. Nine candidate genes were identified. Clinical relevance of these observations is supported by case studies. Clinical implications and the significance to human lupus and other diseases are presented.
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影响因子：
4.7
作者：
Hahn, Bevra H.;McMahon, Maureen A.;Wilkinson, Alan;Wallace, W. Dean;Daikh, David I.;Fitzgerald, John D.;Karpouzas, George A.;Merrill, Joan T.;Wallace, Daniel J.;Yazdany, Jinoos;Ramsey-Goldman, Rosalind;Singh, Karandeep;Khalighi, Mazdak;Choi, Soo-In;Gogia, Maneesh;Kafaja, Suzanne;Kamgar, Mohammad;Lau, Christine;Martin, William J.;Parikh, Sefali;Peng, Justin;Rastogi, Anjay;Chen, Weiling;Grossman, Jennifer M.
通讯作者：
Grossman, Jennifer M.
影响因子：
56.9
作者：
Kumar, Kirthi Raman;Li, Liunan;Mohan, Chandra
通讯作者：
Mohan, Chandra
影响因子：
4.4
作者：
Jacob, Chaim O.;Pricop, Luminita;Stohl, William
通讯作者：
Stohl, William
影响因子：
4.4
作者：
Schiffer, Lena;Bethunaickan, Ramalingam;Davidson, Anne
通讯作者：
Davidson, Anne
DOI：
10.4049/jimmunol.1003010
发表时间：
2011-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bethunaickan R;Berthier CC;Ramanujam M;Sahu R;Zhang W;Sun Y;Bottinger EP;Ivashkiv L;Kretzler M;Davidson A
通讯作者：
Davidson A