The adrenal secretion of catecholamines during systemic metabolic acidosis in fetal sheep.
The adrenal secretion of catecholamines during systemic metabolic acidosis in fetal sheep.
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胎羊全身代谢性酸中毒期间儿茶酚胺的肾上腺分泌。
DOI：
10.1159/000244475
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Jackson,BT
中科院分区：
文献类型：
--
作者：
Cohn,HE;Piasecki,GJ;Cohen,WR;Jackson,BT
本研究旨在确定代谢性酸血症本身是否刺激胎羊肾上腺髓质分泌儿茶酚胺（CA）。在实验设计中考虑了低O2含量的潜在混杂效应，该混杂效应由氧合血红蛋白解离曲线随酸血症的右移所消除。研究了胎羊在基线、对照（生理盐水输注）和酸血症（15%和30%乳酸输注）期间的血流动力学值、血气、O2含量、乳酸和葡萄糖浓度以及肾上腺CA分泌率和血浆CA水平。实验是在全身麻醉下进行的准备性手术恢复后进行的。输注生理盐水后，动脉pH值未发生变化。在15%和30%乳酸输注期间，pH值分别降至7.23和7.09，而乳酸浓度分别增加了4.7和10倍。在30%乳酸输注期间，动脉PCO2从50升高至58 mmHg。胎儿CA分泌和血浆浓度在生理盐水或15或30%乳酸输注期间没有变化。此外，血流动力学参数并没有表明CA分泌增加。总之，我们没有发现代谢性酸中毒刺激肾上腺CA分泌的证据。
This study was undertaken to determine whether or not metabolic acidemia per se stimulates catecholamine (CA) secretion from the adrenal medulla in fetal sheep. The potential confounding effect of low O2content, occasioned by the right shift in the oxyhemoglobin dissociation curve with acidemia, was taken into account in experimental design. Hemodynamic values, blood gases, O2content, lactate and glucose concentrations and adrenal CA secretion rates and plasma CA levels were studied in fetal sheep at baseline and during control (saline infusion) and acidemic (15 and 30% lactic acid infusion) periods. Experiments were conducted after recovery from preparative operations performed under general anesthesia. Arterial pH did not change with saline infusion. During 15 and 30% lactic acid infusions, pH fell to 7.23 and 7.09, respectively, as lactate concentrations increased 4.7 and 10 times. Arterial PCO2increased from 50 to 58 torr during 30% lactic acid infusion. Fetal CA secretion and plasma concentrations did not change during saline, or 15 or 30% lactic acid infusions. Moreover, hemodynamic parameters did not indicate increased CA secretion. In conclusion, we found no evidence for stimulation of adrenal CA secretion by metabolic acidosis.