A role for lung retention in the sense of retronasal smell.
A role for lung retention in the sense of retronasal smell.
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DOI：
10.1007/s12078-015-9181-z
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发表时间：
2015-08-01
影响因子：
1
通讯作者：
Verhagen JV
中科院分区：
文献类型：
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作者：
Verhagen JV
在嗅觉中，气味通常会在进入鼻子的过程中占用肺部，从而唤起鼻后气味。当肺部在吸烟/蒸发过程中有第一次通过效应时，以及在闻到气味后呼出时，这一点最为明显。肺部充当气味的水槽，这既可以减少鼻后气味浓度，也可以减少气味混合物的组成。肺滞留是量化洗涤效果的一种简单方法。肺滞留已经在环境毒理学的背景下进行了研究，并已知许多挥发性有机化合物。关于人类肺部滞留的现有数据表明，肺部可能对气味感知有很大影响，这可能在很大程度上取决于主动采样的特殊性，如嗅探、吸烟和蒸发。对肺滞留的暂时性措施和模型提出了建议。
In olfaction, odors typically engage the lungs on the way to the nose to evoke retronasal smell. This is most notable when the lung has a first pass effect during smoking/vaping, but also upon exhaling after sniffing an odor. The lungs act as a sink for odors, which can both reduce the retronasal odor concentration and the odor mixture makeup. Lung retention is a simple measure that quantifies the effectiveness of the sink. Lung retention has been studied in the context of environmental toxicology and is known for many volatile organic compounds. Available data on human lung retention suggests that the lungs may have a large impact on odor perception, and that this may depend heavily on the specifics of active sampling such as sniffing, smoking and vaping. Suggestions are included for transient measures and models of lung retention.