Association between insomnia symptoms and mortality: a prospective study of U.S. men.
Association between insomnia symptoms and mortality: a prospective study of U.S. men.
复制标题
DOI：
10.1161/circulationaha.113.004500
复制
发表时间：
2014-02-18
期刊：
影响因子：
37.8
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Li Y;Zhang X;Winkelman JW;Redline S;Hu FB;Stampfer M;Ma J;Gao X
失眠主诉在老年人中很常见，可能与死亡风险有关。然而，关于这种联系的证据是复杂的。因此，我们前瞻性地研究了在6年的随访中，有失眠症状的男性死亡风险是否增加。一项前瞻性队列研究对23447名美国男性进行了跟踪调查，该研究报告了2004年失眠症状，并在2010年对其进行了跟踪调查。死亡人数是通过州生命统计记录、国家死亡指数、家庭报告和邮政系统确定的。我们记录了6年(2004-2010)随访期间的2025例死亡病例。总死亡率的多变量调整危险比为：入睡困难1.25(95%可信区间：1.04-1.50)，睡眠维持困难1.09(95%可信区间：0.97-1.24)，清晨醒来1.04(95%可信区间：0.88-1.22)，非恢复性睡眠1.24(95%可信区间：1.05-1.46)，在调整年龄后，比较有这些症状的男性和没有这些症状的男性，生活方式因素和常见慢性病的存在。与没有这些症状的男性相比，入睡困难和非恢复性睡眠的男性心血管死亡风险分别增加55%(HR：1.55；95%CI：1.19-2.04；P-趋势=0.01)和32%(HR：1.32；95%CI：1.02-1.72；P-趋势=0.002)。一些失眠症状，特别是入睡困难和非恢复性睡眠，与略高的死亡风险有关。
Insomnia complaints are common in older adults and may be associated with mortality risk. However, evidence regarding this association is mixed. We thus prospectively examined whether men with insomnia symptoms had an increased risk of mortality during 6 years of follow-up. A prospective cohort study of 23,447 US men participating in the Health Professionals Follow-up Study and free of cancer, reported on insomnia symptoms in 2004 were followed through 2010. Deaths were identified from state vital statistic records, the National Death Index, family reports, and the postal system. We documented 2025 deaths during 6 years of follow-up (2004-2010). The multivariable-adjusted hazard ratios (HRs) of total mortality were 1.25 (95% confidence interval (CI):1.04-1.50) for difficulty initiating sleep, 1.09 (95%CI:0.97-1.24) for difficulty maintaining sleep, 1.04 (95%CI:0.88-1.22) for early-morning awakenings, and 1.24 (95%CI:1.05-1.46) for non-restorative sleep, comparing men with those symptoms most of the time to men without those symptoms, after adjusting for age, lifestyle factors and presence of common chronic conditions. Men with difficulty initiating sleep and non-restorative sleep most of the time had a 55% (HR:1.55; 95% CI:1.19-2.04; P-trend= 0.01) and 32% (HR:1.32; 95% CI:1.02-1.72; P-trend=0.002) increased risk of CVD mortality, respectively, relative to men without those symptoms. Some insomnia symptoms, especially difficulty initiating asleep and non-restorative sleep, are associated with a modestly higher risk of mortality.