Chitosan/alginate nanoparticles stabilized by poloxamer for the controlled release of 5‐fluorouracil
Chitosan/alginate nanoparticles stabilized by poloxamer for the controlled release of 5‐fluorouracil
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DOI：
10.1002/app.32083
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发表时间：
2010-08
影响因子：
3
通讯作者：
Jinfeng Xing;Liandong Deng;Anjie Dong
中科院分区：
文献类型：
--
作者：
Jinfeng Xing;Liandong Deng;Anjie Dong
本研究以波洛沙姆为表面活性剂，制备了负载5-氟尿嘧啶（5-FU）的壳聚糖(CS)/海藻酸盐（Alg）纳米颗粒。研究了Alg浓度、CS/Alg质量比和poloxomer浓度对5- fu负载CS/Alg NPs性能的影响。动态光散射和透射电镜结果表明，获得了稳定的5- fu负载CS/Alg NPs，其尺寸约为200 nm，具有低尺寸的多分散体。此外，研究了5- fu负载的CS/Alg NPs在pH 7.4的磷酸盐缓冲液中的体外释放。结果表明，5-FU的包封率与给药量（DFA）、波洛沙姆浓度、Alg浓度和CS浓度有关。而5- fu负载CS/Alg NPs的体外释放率仅与DFA、Alg浓度和CS浓度有关，与波洛沙姆浓度无关。CS/Alg NPs的5-FU释放时间可控制在12 h以上。本研究表明，经poloxomer稳定的CS/Alg NPs可作为5-FU控释的合适候选物。©2010 Wiley期刊公司高分子学报，2010
In this study, stable 5-fluorouracil (5-FU)-loaded chitosan (CS)/alginate (Alg) nanoparticles (NPs) were prepared with poloxamer as a surfactant. The effects of the Alg concentration, CS/Alg weight ratio, and poloxamer concentration on the properties of the 5-FU-loaded CS/Alg NPs were studied. The results of dynamic light scattering and transmission electron microscopy indicated that stable 5-FU-loaded CS/Alg NPs of around 200 nm with low-size polydispersities were achieved. Furthermore, the in vitro release of the 5-FU-loaded CS/Alg NPs was investigated in phosphate buffer solution at pH 7.4. The results show that the encapsulation efficiency of 5-FU depended on the drug feeding amount (DFA), poloxamer concentration, Alg concentration, and CS concentration. However, the in vitro release rate of the 5-FU-loaded CS/Alg NPs was only related to the DFA, Alg concentration, and CS concentration and was independent of the poloxamer concentration. The time of 5-FU release from the CS/Alg NPs could becontrolled to be sustained for more than 12 h. According to this study, CS/Alg NPs stabilized by poloxamer could serve as a suitable candidate for the controlled release of 5-FU. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010