Memory B and T cells.
Memory B and T cells.
复制标题
记忆B细胞和T细胞。
DOI：
10.1146/annurev.iy.09.040191.001205
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发表时间：
1991
影响因子：
29.7
通讯作者：
Yin,XM
中科院分区：
文献类型：
--
作者：
Vitetta,ES;Berton,MT;Burger,C;Kepron,M;Lee,WT;Yin,XM
免疫系统的三个显著而独特的特征是特异性、多样性和记忆。免疫记忆涉及T细胞和B细胞，并导致更快、亲和力更高的二次抗体应答，并导致非IgM同种型IG的分泌。在这篇综述中，我们讨论了记忆T和B细胞的特性，它们的特异性受体，以及在这些细胞的产生和激活过程中发生在细胞核和细胞表面的事件。虽然记忆T细胞和B细胞使用不同的机制来完善记忆，但有许多有趣的类比：淋巴因子与抗体，B细胞抗原受体的亲和力成熟与T细胞上粘附分子的上调。最后，我们讨论了这些细胞在健康和疾病中的重要性，并提出了关于这些细胞的其他信息可能对免疫反应的操纵产生的影响。
Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs up regulation of adhesion mol ecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.