CLOSED-LOOP SEIZURE CONTROL WITH VERY HIGH FREQUENCY ELECTRICAL STIMULATION AT SEIZURE ONSET IN THE GAERS MODEL OF ABSENCE EPILEPSY
CLOSED-LOOP SEIZURE CONTROL WITH VERY HIGH FREQUENCY ELECTRICAL STIMULATION AT SEIZURE ONSET IN THE GAERS MODEL OF ABSENCE EPILEPSY
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DOI：
10.1142/s0129065711002717
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发表时间：
2011-04-01
影响因子：
8
通讯作者：
Cook, Mark J.
中科院分区：
文献类型：
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作者：
Nelson, Timothy S.;Suhr, Courtney L.;Cook, Mark J.
创建了用于自动检测和控制癫痫发作的闭环系统，并在来自斯特拉斯堡（GAERS）大鼠的三只遗传性失神癫痫大鼠中进行了测试。在这项初步研究中，使用一组四种脑电图特征来检测癫痫发作，并提供三种不同的电刺激策略（标准（130Hz）、极高（500Hz）和超高（1000Hz））来终止癫痫发作。与非刺激（对照）癫痫发作相比，所有三种刺激策略的癫痫发作持续时间均显着缩短。我们使用电刺激结束后持续存在的癫痫样放电的平均癫痫发作持续时间作为刺激功效的衡量标准。与标准方法刺激的癫痫持续时间（7.0 s +/- 10.1）相比，极高频率和超高频刺激策略在缩短癫痫持续时间方面更有效（分别为 1.3 +/- 2.2 s 和 3.5 +/- 6.4 s）。需要进一步的研究来进一步了解这种治疗效果的传递机制，以及与标准电刺激方法相比，甚高频和超高频刺激策略的哪些新颖方面可能有助于改善癫痫发作缓解性能。
A closed-loop system for the automated detection and control of epileptic seizures was created and tested in three Genetic Absence Epilepsy Rats from Strasbourg (GAERS) rats. In this preliminary study, a set of four EEG features were used to detect seizures and three different electrical stimulation strategies (standard (130Hz), very high (500Hz) and ultra high (1000Hz)) were delivered to terminate seizures. Seizure durations were significantly shorter with all three stimulation strategies when compared to non-stimulated (control) seizures. We used mean seizure duration of epileptiform discharges persisting beyond the end of electrical stimulation as a measure of stimulus efficacy. When compared to the duration of seizures stimulated in the standard approach (7.0 s +/- 10.1), both very high and ultra high frequency stimulation strategies were more effective at shortening seizure durations (1.3 +/- 2.2 s and 3.5 +/- 6.4 s respectively). Further studies are warranted to further understand the mechanisms by which this therapeutic effect may be conveyed, and which of the novel aspects of the very high and ultra high frequency stimulation strategies may have contributed to the improvement in seizure abatement performance when compared to standard electrical stimulation approaches.