High-Pressure Clinical-Scale 87% Parahydrogen Generator
High-Pressure Clinical-Scale 87% Parahydrogen Generator
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DOI：
10.1021/acs.analchem.0c03358
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发表时间：
2020-12-01
影响因子：
7.4
通讯作者：
Chekmenev, Eduard Y.
中科院分区：
文献类型：
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作者：
Birchall, Jonathan R.;Coffey, Aaron M.;Chekmenev, Eduard Y.
我们提出了一种自动仲氢发生器（Para-Sun），用于仲氢诱导极化（PHIP）和高压可逆交换信号放大（SABRE）的临床规模应用。该装置采用真空泵送的Sunpower低温冷却器（通常用于冷却蜂窝网络天线），以在低至类似于40 K的温度和类似于490 PSI的最大出口压力下实现高达类似于87%的仲氢富集。设备在1小时内达到目标温度设定点。它使用FeO（OH）催化剂进行邻位到对位的转化。质量流量控制器（MFC）促进H-2气体以每分钟150标准立方厘米（sccm）的速率的受控流动。这种设计弥合了基本的50%富集液氮浴和昂贵得多的、采用高H-2通量的接近单一富集配置之间的差距，
We present an automated parahydrogen generator (Para-Sun) for clinical-scale applications in parahydrogen-induced polarization (PHIP) and signal amplification by reversible exchange (SABRE) at high pressures. The device employs a vacuum-pumped, Sunpower cryo-cooler (typically employed for cooling cellular network antennas) to achieve up to similar to 87% parahydrogen enrichment at a temperature as low as similar to 40 K and a maximum outlet pressure of similar to 490 PSI. The device reaches the target temperature set-point in under 1 h. It employs a FeO (OH) catalyst for the ortho- to para-state conversion. A mass-flow controller (MFC) facilitates the controlled flow of H-2 gas at a rate of 150 standard cubic centimeters per minute sccm). This design bridges the gap between rudimentary 50% enrichment liquid-N 2 baths and far costlier, near-unity-enrichment configurations employing high-H-2 throughputs and