An update on the genetics of psoriasis
An update on the genetics of psoriasis
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DOI：
10.1016/s0733-8635(03)00125-6
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发表时间：
2004-10-01
影响因子：
2.4
通讯作者：
Barker, JN
中科院分区：
文献类型：
--
作者：
Capon, F;Trembath, RC;Barker, JN
银屑病是一种复杂的炎症性疾病，其发病机制可能需要几个基因和环境触发因素的作用。尽管多因素条件的研究带来了困难，但在银屑病的分子遗传学基础方面已经取得了重大进展。长期以来，人们一直认为染色体6p21上的主要组织相容性复合体(MHC)区域是银屑病易感性的主要决定因素。由于可能发生遗传异质性，整个基因组中非MHC易感区域的识别受到了阻碍。尽管如此，通过研究，包括对大量患者队列的协作分析，以及通过观察牛皮癣和特应性皮炎易感区域之间的重叠，已经获得了指定一些非MHC基因座的证据。
Psoriasis is a complex inflammatory disorder whose pathogenesis is likely to require the contribution of several genes and environmental triggers. Despite the difficulties posed by the study of multifactorial conditions, significant progress has been achieved in relation to the molecular genetic basis of psoriasis. It has long been recognized that the major histocompatibility complex (MHC) region on chromosome 6p21 harbors the main determinant conferring psoriasis susceptibility. The identification of non-MHC susceptibility regions across the genome has been hindered by the likely occurrence of genetic heterogeneity. Nonetheless, evidence for the assignment of a number of non-MHC loci has been achieved through studies, including the collaborative analysis of large patient cohorts, and also through the observation of overlap between psoriasis and atopic dermatitis susceptibility regions.