Residential magnetic fields, light-at-night, and nocturnal urinary 6-sulfatoxymelatonin concentration in women
Residential magnetic fields, light-at-night, and nocturnal urinary 6-sulfatoxymelatonin concentration in women
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DOI：
10.1093/aje/154.7.591
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发表时间：
2001-10-01
影响因子：
5
通讯作者：
Stevens, RG
中科院分区：
文献类型：
--
作者：
Davis, S;Kaune, WT;Stevens, RG
暴露于 60 Hz 磁场可能会抑制褪黑激素在夜间的正常升高，从而增加患乳腺癌的风险。华盛顿州的这项 1994-1996 年研究调查了 203 名 20-74 岁无乳腺癌病史的女性，这种暴露是否与夜间尿中 6-磺酰氧基褪黑素浓度较低有关。每位女性都接受了采访，并提供了一年中两个不同季节 72 小时内的以下数据：1) 每 30 秒在她的卧室测量一次磁场和环境光，2) 每 30 秒测量一次个人磁场，以及 3) 连续三个晚上的完整夜间尿液样本。夜间尿 6-磺酰氧基褪黑激素水平较低与日照时间较长、年龄较大、体重指数较高、当前饮酒量以及当前使用 β 受体阻滞剂、钙通道阻滞剂或精神药物等药物有关。调整这些因素后，较高的卧室磁场水平与当晚尿中 6-磺酰氧基褪黑素浓度显着降低相关，主要是在使用这些药物的女性以及一年中黑暗时间最少的时期。这些结果表明，暴露于夜间住宅 60 Hz 磁场可以抑制褪黑激素在夜间的正常升高。
Exposure to 60-Hz magnetic fields may increase breast cancer risk by suppressing the normal nocturnal rise in melatonin. This 1994-1996 Washington State study investigated whether such exposure was associated with lower nocturnal urinary concentration of 6-sulfatoxymelatonin in 203 women aged 20-74 years with no history of breast cancer. Each woman was interviewed and provided data on the following for a 72-hour period at two different seasons of the year: 1) magnetic field and ambient light measured every 30 seconds in her bedroom, 2) personal magnetic field measured at 30-second intervals, and 3) complete nighttime urine samples on three consecutive nights. Lower nocturnal urinary 6-sulfatoxymelatonin level was associated with more hours of daylight, older age, higher body mass index, current alcohol consumption, and current use of medications classified as beta blockers, calcium channel blockers, or psychotropics. After adjustment for these factors, higher bedroom magnetic field level was associated with significantly lower urinary concentration of 6-sulfatoxymelatonin during the same night, primarily in women who used these medications and during times of the year with the fewest hours of darkness. These results suggest that exposure to nighttime residential 60-Hz magnetic fields can depress the normal nocturnal rise in melatonin.