JASPAR:: an open-access database for eukaryotic transcription factor binding profiles
JASPAR:: an open-access database for eukaryotic transcription factor binding profiles
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DOI：
10.1093/nar/gkh012
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Lenhard, B
中科院分区：
文献类型：
--
作者：
Sandelin, A;Alkema, W;Lenhard, B
基因组序列中调控区的分析主要基于对潜在转录因子结合位点的检测。用于表示转录因子结合特异性的优选模型被称为位置特异性评分矩阵。JASPAR是多细胞真核生物的注释的、高质量的、基于基质的转录因子结合位点谱的开放访问数据库。这些图谱完全来自实验证明能结合转录因子的核苷酸序列集。该数据库由用于浏览、搜索和子集选择的网络界面、在线序列分析实用程序和一套用于调控区的全基因组和比较基因组分析的编程工具来补充。JASPAR可以在http：//jaspar上找到。cgb.ki.se.
The analysis of regulatory regions in genome sequences is strongly based on the detection of potential transcription factor binding sites. The preferred models for representation of transcription factor binding specificity have been termed position-specific scoring matrices. JASPAR is an open-access database of annotated, high-quality, matrix-based transcription factor binding site profiles for multicellular eukaryotes. The profiles were derived exclusively from sets of nucleotide sequences experimentally demonstrated to bind transcription factors. The database is complemented by a web interface for browsing, searching and subset selection, an online sequence analysis utility and a suite of programming tools for genomewide and comparative genomic analysis of regulatory regions. JASPAR is available at http://jaspar. cgb.ki.se.