FATTY-ACIDS MARKEDLY LOWER THE THRESHOLD FOR HALOTHANE-INDUCED CALCIUM RELEASE FROM THE TERMINAL CISTERNAE IN HUMAN AND PORCINE NORMAL AND MALIGNANT HYPERTHERMIA SUSCEPTIBLE SKELETAL-MUSCLE
FATTY-ACIDS MARKEDLY LOWER THE THRESHOLD FOR HALOTHANE-INDUCED CALCIUM RELEASE FROM THE TERMINAL CISTERNAE IN HUMAN AND PORCINE NORMAL AND MALIGNANT HYPERTHERMIA SUSCEPTIBLE SKELETAL-MUSCLE
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DOI：
10.1016/0024-3205(91)90060-o
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发表时间：
1991-01-01
期刊：
影响因子：
6.1
通讯作者：
ROSENBERG, H
中科院分区：
文献类型：
--
作者：
FLETCHER, JE;MAYERBERGER, S;ROSENBERG, H
恶性高热是由于骨骼肌中的钙离子水平对麻醉剂（包括氟烷）的反应异常增加而引起的。由于脂肪酸的产生是升高的骨骼肌从恶性高热的个人，脂肪酸的氟烷诱导的钙释放的阈值的影响进行了检查。在不存在脂肪酸的情况下，氟烷导致从猪和人的重肌浆网组分中释放Ca2+，但仅在高于临床相关范围的浓度下。油酸（20 μ M），一种不饱和脂肪酸，降低了氟烷诱导Ca2+释放的阈值，使其达到麻醉浓度。硬脂酸是一种饱和脂肪酸，对氟烷作用阈值的影响较小。恶性高热肌肉对氟烷的更大的敏感性可以通过脂肪酸产生的升高来解释。
Malignant hyperthermia is caused by an abnormal increase in Ca2+ levels In skeletal muscle in response to anesthetics, including halothane. Since fatty acid production is elevated in skeletal muscle from individuals with malignant hyperthermia, the effects of fatty acids on the threshold of halothane-induced Ca2+ release were examined. In the absence of fatty acids halothane caused Ca2+ release from porcine and human heavy sarcoplasmic reticulum fractions, but only at concentrations above the clinically relevant range. Oleic acid (20-mu-M), an unsaturated fatty acid, reduced the threshold at which halothane induced Ca2+ release to concentrations used for anesthesia. Stearic acid, a saturated fatty acid had considerably less effect on the threshold of halothane action. The greater sensitivity of malignant hyperthermia muscle to halothane can be explained by elevated fatty acid production.