Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes
Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes
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DOI：
10.1063/1.3290633
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发表时间：
2010-01-11
影响因子：
4
通讯作者：
Altug, Hatice
中科院分区：
文献类型：
--
作者：
Yanik, Ahmet Ali;Huang, Min;Altug, Hatice
生物传感器的性能通常受到传感区域周围产生的耗尽区的限制，这阻碍了分析物的有效传输。为了克服这一限制，我们提出并展示了一种纳米等离子体纳米流体传感器，能够有针对性地将分析物传递到传感器表面，并显着提高传质效率。我们的传感平台是基于悬浮等离子体纳米孔中的非凡光传输效应。该方案允许通过等离子体/纳米流体孔连接微流体通道的单独层来三维控制流体流动。为了实现所提出的传感器平台，我们还介绍了一种剥离自由纳米加工方法。
Performances of the biosensors are often limited by the depletion zones created around the sensing area which impede the effective analyte transport. To overcome this limitation, we propose and demonstrate a nanoplasmonic-nanofluidic sensor enabling targeted delivery of analytes to the sensor surface with dramatic improvements in mass transport efficiency. Our sensing platform is based on extraordinary light transmission effect in suspended plasmonic nanoholes. This scheme allows three-dimensional control of the fluidic flow by connecting separate layers of microfluidic channels through plasmonic/nanofluidic holes. To implement the proposed sensor platform, we also introduce a lift-off free nanofabrication method.