Low Rates of Hepatotoxicity in HIV-infected Children on Anti-retroviral Therapy with and without Isoniazid Prophylaxis
Low Rates of Hepatotoxicity in HIV-infected Children on Anti-retroviral Therapy with and without Isoniazid Prophylaxis
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DOI：
10.1093/tropej/fmp079
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发表时间：
2010-06-01
影响因子：
2
通讯作者：
Zar, Heather
中科院分区：
文献类型：
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作者：
Gray, Diane;Nuttall, James;Zar, Heather
本研究调查了HIV感染儿童在抗逆转录病毒治疗（ART）期间肝毒性的发生率以及合并使用异烟肼预防性治疗的影响。这是对1998年9月至2005年11月期间开始抗逆转录病毒治疗或接受随访的艾滋病毒感染儿童的回顾性队列分析。丙氨酸转移酶水平在基线时，在1，3和6个月，然后6个月后测量。在纳入研究的598名儿童中，425名仅服用ART，73名ART和异烟肼，39名仅服用异烟肼，61名既不服用异烟肼也不服用ART。与对照组相比，在2年的时间内，ART伴或不伴异烟肼的肝毒性风险没有增加。19例（3.4%）儿童发生3级或4级ALT升高，无暴发性肝衰竭病例。严重肝脏事件在接受ART或异烟肼治疗的儿童中不常见。ART和同时使用异烟肼预防性治疗不会增加肝毒性风险。
This study investigates the incidence of hepatotoxicity in HIV-infected children during anti-retroviral therapy (ART) and the impact of concomitant use of isoniazid preventive therapy. It is a retrospective cohort analysis of HIV-infected children who commenced ART or were followed up between September 1998 and November 2005. Alanine transferase levels were measured at baseline, at 1, 3 and 6 months and then 6 monthly thereafter. Of the 598 children included in the study, 425 were taking ART alone, 73 ART and isoniazid, 39 isoniazid alone and 61 neither isoniazid nor ART. There was no increased risk of hepatotoxicity with ART with or without isoniazid compared to the control group over a 2-year period. Grade 3 or 4 ALT elevations occurred in 19 (3.4%) children, with no cases of fulminant hepatic failure. Severe hepatic events are uncommon in children on ART or isoniazid. There is no increased risk of hepatotoxicity with ART and concurrent isoniazid preventive therapy.