Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults.
Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults.
复制标题
人类免疫缺陷病毒感染成人的代谢异常和冠心病风险。
DOI：
10.1089/met.2009.0094
复制
发表时间：
2010
影响因子：
2.1
通讯作者：
Lee,KathrynA
中科院分区：
文献类型：
--
作者：
Pullinger,CliveR;Aouizerat,BradleyE;Gay,Caryl;Coggins,Traci;Movsesyan,Irina;Davis,Harvey;Kane,JohnP;Portillo,Carmen;Lee,KathrynA
背景：代谢综合征是心血管疾病和糖尿病的危险因素的组合，据报道，在人类免疫缺陷病毒 (HIV) 感染者中，代谢综合征的发病率有所增加。方法：在一组感染 HIV 的成年人中，我们检查了有助于定义代谢综合征和估计冠心病 (CHD) 10 年风险的参数。该研究组由 296 名混合种族参与者（217 名男性和 79 名女性）组成，平均年龄为 45.3 岁。结果：代谢综合征患病率相当高（30.0%），50 岁以上人群的患病率增至 42.5%。患有代谢综合征的人病毒载量较低。腹部肥胖的女性（59.5%）多于男性（20.7%，P<0.001）。女性血糖升高的频率（37.2%）高于男性（16.9%，P= 0.004）。两性均出现高密度脂蛋白胆固醇（HDL-C）下降和血压升高的现象。高甘油三酯血症在非裔美国人中不太常见。在50岁以下人群中，男性10年冠心病风险评分是女性的两倍（6.2% vs 2.7%，P< 0.001）。在老年参与者中，两性之间的风险相似，其中三分之一的得分超过 10%。 结论：代谢综合征的患病率高于大多数其他 HIV 人群。患有这种综合症的人的病毒载量明显较低。代谢综合征患者的 10 年平均弗雷明汉心血管风险 (FCR) 评分几乎翻倍。研究人员和临床医生在评估 HIV 感染患者是否存在与代谢综合征相关的风险时，都应考虑年龄和性别。
Background:Metabolic syndrome is a combination of risk factors for cardiovascular disease and diabetes, It has been reported to be increased in human immunodeficiency virus (HIV)–infected individuals.Methods:In a cohort of HIV-infected adults we examined parameters that contribute to defining the metabolic syndrome and to estimating the 10-year risk of coronary heart disease (CHD). The study group consisted of 296 participants (217 men and 79 women) of mixed ethnicity with a mean age of 45.3 years.Results:There was an appreciable prevalence of metabolic syndrome (30.0%), with the frequency increasing to 42.5% in those over 50 years of age. Those with the metabolic syndrome had a lower viral load. More women had abdominal obesity (59.5%) than men (20.7%,P< 0.001). The frequency of elevated plasma glucose was higher in females (37.2%) compared to males (16.9%,P= 0.004). High frequencies of decreased high-density lipoprotein cholesterol (HDL-C) and elevated blood pressure were seen in both sexes. Hypertriglyceridemia was less prevalent in African Americans. In those under 50 years of age, the 10-year CHD risk score for men was double that for women (6.2% vs 2.7%,P< 0.001). In older participants, the risk was similar between the sexes, with a third having scores over 10%.Conclusions:The prevalence of metabolic syndrome was higher than in most other HIV cohorts. Those with the syndrome had significantly lower viral loads. Mean 10-year Framingham Cardiovascular Risk (FCR) scores were nearly doubled for those with metabolic syndrome. Both researchers and clinicians should consider age as well as sex when assessing patients with HIV infection for risks associated with metabolic syndrome.