Fetal Alcohol Spectrum Disorders: A Population Based Study of Premature Mortality Rates in the Mothers
Fetal Alcohol Spectrum Disorders: A Population Based Study of Premature Mortality Rates in the Mothers
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DOI：
10.1007/s10995-011-0844-3
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发表时间：
2012-08-01
影响因子：
2.3
通讯作者：
Burd, Larry
中科院分区：
文献类型：
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作者：
Li, Qing;Fisher, Wayne W.;Burd, Larry
胎儿酒精谱系障碍 (FASD) 与 FASD 患者及其兄弟姐妹的死亡风险增加相关。在这项研究中，我们使用回顾性病例对照方法检查了 FASD 儿童的亲生母亲的死亡率。我们利用北达科他州 FASD 登记处查找 FASD 儿童的出生证明，并用这些出生证明来识别出生母亲。然后我们寻找母亲的死亡证明。然后，我们将生母的死亡率与年龄匹配的对照组（由与生母同一年出生和死亡的所有北达科他州妇女组成）进行了比较。胎儿酒精谱系障碍 (FASD) 儿童的生母死亡率为 15/304 = 4.93%； （95% CI 2.44-7.43%）。与 FASD 母亲同年出生的对照母亲的死亡率为 126/114,714 = 0.11% (95% CI 0.09-0.13%)。患有 FASD 儿童的母亲的死亡风险增加了 44.82 倍，其中 87% 的死亡发生在 50 岁以下的女性中。三种死因（癌症、受伤和酒精相关疾病）占 FASD 儿童母亲死亡的 67%。 FASD 的诊断是诊断患有 FASD 的儿童母亲过早死亡的重要风险标志。应鼓励这些妇女接受药物滥用治疗。
Fetal alcohol spectrum disorders (FASD) are associated with an increase in risk for mortality for people with an FASD and their siblings. In this study we examine mortality rates of birth mothers of children with FASD, using a retrospective case control methodology. We utilized the North Dakota FASD Registry to locate birth certificates for children with FASD which we used to identify birth mothers. We then searched for mothers' death certificates. We then compared the mortality rates of the birth mothers with an age matched control group comprised of all North Dakota women who were born and died in the same year as the birth mother. The birth mothers of children with FASD had a mortality rate of 15/304 = 4.93%; (95% CI 2.44-7.43%). The mortality rate for control mothers born in same years as the FASD mothers was 126/114,714 = 0.11% (95% CI 0.09-0.13%). Mothers of children with an FASD had a 44.82 fold increase in mortality risk and 87% of the deaths occurred in women under the age of 50. Three causes of death (cancer, injuries, and alcohol related disease) accounted for 67% of the deaths in the mothers of children with FASD. A diagnosis of FASD is an important risk marker for premature death in the mothers of children diagnosed with an FASD. These women should be encouraged to enter substance abuse treatment.