In-situ electrospinning of thymol-loaded polyurethane fibrous membranes for waterproof, breathable, and antibacterial wound dressing application
In-situ electrospinning of thymol-loaded polyurethane fibrous membranes for waterproof, breathable, and antibacterial wound dressing application
复制标题
原位静电纺丝负载百里酚的聚氨酯纤维膜，用于防水、透气和抗菌伤口敷料应用
DOI：
10.1016/j.jcis.2021.02.048
复制
发表时间：
2021-03-03
影响因子：
9.9
通讯作者：
Ding, Bin
中科院分区：
文献类型：
--
作者：
Yue, Yunpeng;Gong, Xiaobao;Ding, Bin
具有优异的耐水性和透湿性的类皮肤柔性膜是伤口敷料领域迫切需要的一种为伤口部位提供舒适和保护的材料。尽管在防水透气膜（W&B）的开发方面已经做出了努力，但适合于不规则创面的防水透气膜作为伤口敷料的原位静电纺丝仍然面临着巨大的挑战。本课题设计了一种具有灌注速度可调（0.05 mL/h ~ 10 mL/h）、高压可达11 kV的多功能便携式静电纺丝装置。采用自制的装置制备了具有抗菌活性的百里香负载乙醇溶性聚氨酯（EPU）类皮肤型W&B纳米纤维膜。最终，由EPU、氟化聚氨酯（FPU）和百里香酚组成的纳米纤维膜结构均匀，静水压力为17.6 cm H2O，防水性能为3.56 kg m(-2) d(-1)，拉伸应力为1.83 MPa，拉伸应变为453%，抗菌活性高。这些结果表明，这种新型装置具有作为一种便携式静电纺丝装置直接在伤口表面制备抗菌膜的潜力，为便携式静电纺丝装置的发展开辟了一条新的途径。(C) 2021爱思唯尔公司版权所有。
Skin-like flexible membrane with excellent water resistance and moisture permeability is an urgent need in the wound dressing field to provide comfort and protection for the wound site. Despite efforts that have been made in the development of waterproof and breathable (W&B) membranes, the in-situ electrospinning of W&B membranes suitable for irregular wound surfaces as wound dressings still faces huge challenges. In the current work, a portable electrospinning device with multi-functions, including adjustable perfusion speed for a large range from 0.05 mL/h to 10 mL/h and high voltage up to 11 kV, was designed. The thymol-loaded ethanol-soluble polyurethane (EPU) skin-like W&B nanofibrous membranes with antibacterial activity were fabricated via the custom-designed device. Ultimately, the resultant nanofibrous membranes composed of EPU, fluorinated polyurethane (FPU), and thymol presented uniform structure, robust waterproofness with the hydrostatic pressure of 17.6 cm H2O, excellent of 3.56 kg m(-2) d(-1), the high tensile stress of 1.83 MPa and tensile strain of 453%, as well as high antibacterial activity. These results demonstrate that the new-type device has potential as a portable electrospinning apparatus for the fabrication of antibacterial membranes directly on the wound surface and puts a new way for the development of portable electrospinning devices. (C) 2021 Elsevier Inc. All rights reserved.