Performance in specific language tasks correlates with regional volume changes in progressive aphasia
Performance in specific language tasks correlates with regional volume changes in progressive aphasia
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DOI：
10.1097/wnn.0b013e31815e6265
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发表时间：
2007-12-01
影响因子：
1.4
通讯作者：
Gorno-Tempini, Maria Luisa
中科院分区：
文献类型：
--
作者：
Amici, Serena;Ogar, Jennifer;Gorno-Tempini, Maria Luisa
背景：长期以来，语言障碍模式一直被临床用来定位中风患者的脑损伤。目的：探讨5 1例神经退行性疾病所致进行性语言障碍患者在4种常用语言任务上的得分与脑灰质丢失之间的关系。方法：采用体素形态计量学方法，对西方失语症成套测验中4种常用语言任务的得分与脑区灰质体积进行相关分析。结果：(1)命名和双侧颞叶的脑体积与各语言任务的得分呈显著正相关；(2)句子重复和左额上回后部；(3)句子理解和左额中下回；(4)语言流利性和左额中下回。讨论：在特定语言任务中的表现与神经退行性疾病所致失语症的局部解剖损害相对应。这些语言测试在鉴别诊断原发进行性失语症变异体方面可能很有用，这些变异体以前被认为与相应解剖区域的损伤有关。
Background: Patterns of language impairment have long been used clinically to localize brain damage in stroke patients. The same approach might be useful in the differential diagnosis of progressive aphasia owing to neurodegenerative disease.Objective: To investigate whether scores on 4 widely used language tasks correlate with regional gray matter loss in 51 patients with progressive language impairment owing to neurodegenerative disease.Method: Scores in the Boston Naming Test and in the "repetition" 11 sequential commands" and the "language fluency," subtests of the Western Aphasia Battery were correlated with voxel-wise gray matter volumes using voxel-based morphometry.Results: Significant positive correlations were found between each language task and regional brain volumes: (1) naming and the bilateral temporal lobes; (2) sentence repetition and the left posterior portion of the superior temporal gyrus; (3) sentence comprehension and the left dorsal middle and inferior frontal gyri; and (4) fluency of language production and the left ventral middle and inferior frontal gyri.Discussion: Performance on specific language tasks corresponds to regional anatomic damage in aphasia owing to neurodegenerative disorders. These language tests might be useful in the differential diagnosis of primary progressive aphasia variants that have been previously associated with damage to corresponding anatomic regions.