Pepluanols C-D, Two Diterpenoids with Two Skeletons from Euphorbia peplus.
Pepluanols C-D, Two Diterpenoids with Two Skeletons from Euphorbia peplus.
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DOI：
10.1021/acs.orglett.8b01114
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发表时间：
2018-05
期刊：
影响因子：
5.2
通讯作者：
Luosheng Wan;Y. Nian;Xingrong Peng;Li-Dong Shao;Xiao-Nian Li;Jian Yang;Ming Zhou;M. Qiu
中科院分区：
文献类型：
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作者：
Luosheng Wan;Y. Nian;Xingrong Peng;Li-Dong Shao;Xiao-Nian Li;Jian Yang;Ming Zhou;M. Qiu
Pepluanol C和D（1和2）分别具有前所未有的5/5/10外，外-[7.2.1]双环十二烷核心和6/6/7/3稠环骨架，从Euphorbia peplus中分离。通过一系列广泛的光谱方法和X射线衍射分析确定了它们的化学结构和绝对构型。此外，在30 μM时，pepluanol C和D对Kv1.3钾通道的峰值电流抑制率分别为31.6 ± 8.3%和30.5 ± 2.8%。
Pepluanols C and D (1 and 2), featuring unprecedented 5/5/10 with out,out-[7.2.1]bicylcododecane core and 6/6/7/3 fused-ring skeletons, respectively, were isolated from Euphorbia peplus. Their chemical structures and absolute configurations were determined by a series of extensive spectroscopic methods, and X-ray diffraction analysis. In addition, pepluanols C and D showed 31.6 ± 8.3% and 30.5 ± 2.8% peak current inhibition on the Kv1.3 potassium channel at 30 μM.