Deciphering the molecular basis of human cardiovascular disease through network biology.
Deciphering the molecular basis of human cardiovascular disease through network biology.
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DOI：
10.1097/hco.0b013e3283515b31
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发表时间：
2012-05
影响因子：
2.3
通讯作者：
Loscalzo J
中科院分区：
文献类型：
--
作者：
Chan SY;White K;Loscalzo J
本文介绍了网络医学的基本概念，并探讨了基于网络的方法预测和改善人类心血管疾病的个体表现的可行性和潜在影响。复杂的心血管疾病很少由单一分子效应器的异常引起，而是几乎总是通过相互连接的网络相互作用的多种病理生物学途径的净结果。在后基因组时代，已经出现了一个框架的潜在复杂性的相互作用的途径，管理分子的行动在人类细胞。因此，网络方法已被开发出来，以更全面地了解那些影响人类疾病的相互联系。“网络医学”已经导致了新的疾病基因和途径的切实发现，以及合理药物开发的改进机制。随着方法的发展，网络医学可以更好地捕捉人类发病机制的复杂性，从而重新定义个性化的疾病分类和治疗。
This review introduces the fundamental concepts of network medicine and explores the feasibility and potential impact of network-based methods on predicting and ameliorating individual manifestations of human cardiovascular disease. Complex cardiovascular diseases rarely result from an abnormality in a single molecular effector, but, rather, nearly always are the net result of multiple pathobiological pathways that interact through an interconnected network. In the post-genomic era, a framework has emerged of the potential complexity of the interacting pathways that govern molecular actions in the human cell. As a result, network approaches have been developed to understand more comprehensively those interconnections that influence human disease. “Network medicine” has already led to tangible discoveries of novel disease genes and pathways as well as improved mechanisms for rational drug development. As methodologies evolve, network medicine may better capture the complexity of human pathogenesis and, thus, re-define personalized disease classification and therapies.