Acute and protracted cocaine abstinence in an outpatient population: A prospective study of mood, sleep and withdrawal symptoms
Acute and protracted cocaine abstinence in an outpatient population: A prospective study of mood, sleep and withdrawal symptoms
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DOI：
10.1016/s0376-8716(99)00126-x
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发表时间：
2000-06-01
影响因子：
4.2
通讯作者：
Brady, KT
中科院分区：
文献类型：
--
作者：
Coffey, SF;Dansky, BS;Brady, KT
本研究通过前瞻性评估24名男性和女性可卡因依赖门诊患者28天内的可卡因戒断监测来解决尚未解决的问题。根据尿液药物筛查和自我报告的物质使用结果，这些患者在评估期间可能戒断了可卡因。在末次使用可卡因后2、5、10、14、21和28天监测戒断相关症状。对于已知复发的患者，在使用可卡因的最后一天后再次开始评估。与可卡因戒断的住院研究结果一致，在28天内报告了负面影响的线性改善，低可卡因渴望和认知技能的增加。同样与可卡因戒断的住院研究一致，在该门诊样本中未观察到阶段性戒断综合征。与住院患者研究不同，未报告睡眠障碍。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
This study addresses unresolved questions about cocaine withdrawal by prospectively assessing monitored cocaine abstinence over 28 days in a sample of 24 male and female cocaine-dependent outpatients. Based on results from urine drug screens and self-reported substance use, it is likely that these patients were abstinent from cocaine during the assessment period. Abstinence-related symptoms were monitored at 2, 5, 10, 14, 21, and 28 days following last cocaine use. For patients who were known to relapse, assessments began again after the last day of cocaine use. Consistent with findings from inpatient studies of cocaine abstinence, linear improvements in negative affect, low cocaine craving, and increases in cognitive skills were reported over the 28 days. Also consistent with inpatient studies of cocaine withdrawal, a phasic withdrawal syndrome was not observed in this outpatient sample. Unlike inpatient studies, no disturbances in sleep were reported. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.