Effect of carboxyhemoglobin on the single breath diffusing capacity: derivation of an empirical correction factor.
Effect of carboxyhemoglobin on the single breath diffusing capacity: derivation of an empirical correction factor.
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碳氧血红蛋白对单次呼吸扩散能力的影响：经验校正因子的推导。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
D. Tashkin
中科院分区：
文献类型：
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作者：
Z. Mohsenifar;D. Tashkin
本文研究了19名健康非吸烟者呼吸CO时产生的不同血COHb浓度对DLco测定值的影响。发现在未校正血液COHb的情况下计算的DLco，对于血液COHb饱和度的每一个百分比增加，都虚假地降低了观察到的基线值的约1%。当测量可能具有升高的COHb血液水平的受试者的DLco时，建议测定血液COHb浓度或平衡的肺泡PCO，以便针对COHb的影响校正DLco。
The effect on measured DLco of different blood concentrations of COHb produced by breathing CO was studied in 19 healthy nonsmoking subjects. The DLco calculated without adjustment for blood COHb was found to be spuriously reduced by approximately 1% of the observed baseline value for each percent increase in blood COHb saturation. When measuring DLco of subjects who are likely to have elevated COHb blood levels, it is recommended that either blood COHb concentration or equilibrated alveolar PCO be determined in order to correct the DLco for the effect of COHb.