Cancer stem cell as a potential therapeutic target in hepatocellular carcinoma.
Cancer stem cell as a potential therapeutic target in hepatocellular carcinoma.
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DOI：
10.2174/156800912803987995
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发表时间：
2012-11
影响因子：
3
通讯作者：
R. Pang;R. Poon
中科院分区：
文献类型：
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作者：
R. Pang;R. Poon
肝细胞癌（HCC）是人类最常见的癌症之一。肝细胞癌是一种化疗耐药的癌症，目前的药物治疗效果有限。因此，HCC患者的预后通常较差。最近的研究表明，具有干细胞特性的癌细胞亚群，称为癌症干细胞（CSC），负责癌症的生长和转移。已经从不同的人HCC细胞系或标本中分离出以包括CD 133、CD 44、CD 90、OV 6、上皮细胞粘附分子（EpCAM）和CD 13的几种标志物为特征的CSC。CSC共享在正常干细胞中发现的许多信号传导途径，例如Wnt、Hedgehog、Notch和转化生长因子-β（TGF-β）途径。这些通路参与CSC的自我更新、分化和存活。有证据表明HCC CSC中这些途径的失调。microRNA在肝癌的信号通路中也起着重要的调节作用，最近的数据表明microRNA在肝癌的CSC中起着重要的作用。肿瘤干细胞的靶向治疗可能提供一种新的策略，比目前靶向大量成熟癌细胞的药物在治疗HCC中更有效。
Hepatocellular carcinoma (HCC) is one of the most common human cancers. HCC is a chemoresistant cancer and the current drug therapy has limited efficacy. As a result, the prognosis of HCC patients is generally poor. Recent studies have demonstrated that a subpopulation of cancer cells with stem cell properties, called cancer stem cells (CSCs), are responsible for growth and metastasis of cancer. CSCs characterized by several markers including CD133, CD44, CD90, OV6, Epithelial cell adhesion molecule (EpCAM) and CD13 have been isolated from different human HCC cell lines or specimens. CSCs share many of the signaling pathways found in normal stem cells, such as Wnt, Hedgehog, Notch and Transforming growth factor-beta (TGF-β) pathways. These pathways are involved in self-renewal, differentiation and survival of CSCs. There is evidence of deregulation of these pathways in HCC CSCs. MicroRNAs also play an important role in regulating signaling pathways in HCC, and recent data suggested an important role of microRNA in CSCs of HCC. Therapeutic targeting of CSCs may provide a novel strategy that is more effective than the current drugs targeting the bulk mature cancer cells in treatment of HCC.