Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats.
Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats.
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DOI：
10.3923/pjbs.2008.1779.1784
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发表时间：
2008-07-15
期刊：
影响因子：
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通讯作者：
Shahi, Majid Mohamad
中科院分区：
文献类型：
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作者：
Haidari, Fatemeh;Rashidi, Mohammad Reza;Shahi, Majid Mohamad
本研究旨在探讨洋葱对正常和高尿酸血症大鼠血清尿酸水平和肝脏黄嘌呤脱氢酶/黄嘌呤氧化酶活性的影响。用氧嗪酸钾250 mg/kg腹腔注射诱发大鼠高尿酸血症。连续7天口服3.5和7.0 mg/kg（-1）天的洋葱能够降低高尿酸血症大鼠的血清尿酸水平，对正常动物中该化合物的水平没有显著影响。此外，洋葱在大鼠肝匀浆体内试验时，黄嘌呤脱氢酶（XDH）和黄嘌呤氧化酶（XO）的活性引起显着的抑制作用。这种作用的效力低于别嘌呤醇。然而，在实验动物中观察到的低尿酸血症效应似乎与XDH和XO活性的变化并不平行，这意味着洋葱可能通过除了简单抑制酶活性之外的其他机制起作用。洋葱的这种降尿酸作用和酶抑制活性使其成为别嘌呤醇的可能替代品，或至少在联合治疗中使别嘌呤醇的副作用最小化，特别是在长期应用中。
The aim of this study was to investigate the effects of onion on serum uric acid levels and hepatic Xanthine Dehydrogenase/Xanthine Oxidase activities in normal and hyperuricemic rats. Hyperuricemia was induced by intraperitoneal injection of 250 mg kg(-1) potassium oxonate in rats. Oral administration of onion at 3.5 and 7.0 mg kg(-1) day(-1) for 7 days was able to reduce serum uric acid levels in hyperuricemic rats with no significant effects on the level of this compound in the normal animals. In addition, onion when tested in vivo on rat liver homogeneities elicited significant inhibitory actions on the Xanthine Dehydrogenase (XDH) and Xanthine Oxidase (XO) activities. This effect resulted less potent than that of allopurinol. However, the hypouricemic effect observed in the experimental animal did not seem to parallel the change in XDH and XO activities, implying that the onion might be acting via other mechanisms apart from simple inhibition of enzyme activities. Such hypouricemic action and enzyme inhibitory activity of onion makes it a possible alternative for allopurinol, or at least in combination therapy to minimize the side-effects of allopurinol, in particular in long-term application.