Inhibition of human killer cells by autologous lymphocytes.
Inhibition of human killer cells by autologous lymphocytes.
复制标题
自体淋巴细胞对人类杀伤细胞的抑制。
作者：
S. Pollack;S. L. Emmons
本研究表明，由K细胞介导的人抗体依赖性细胞毒性（ADCC）可被自体淋巴细胞抑制。抑制剂的活性存在于缺乏Fc受体的淋巴细胞群中，即携带Fc受体的淋巴细胞在固定的富集物上耗竭以抑制。T细胞富集的群体不会抑制。由于大量添加绵羊或鸡红细胞并不降低ADCC，因此其作用不是位阻抑制。在没有添加抗体的情况下，NK细胞介导的自发细胞毒性不受fcr缺失群体的抑制，这表明K细胞和NK细胞在这方面存在差异。
Human antibody-dependent cellular cytotoxicity (ADCC) mediated by K cells is shown in this study to be inhibited by autologous lymphocytes. Inhibitor activity resides in a population of lymphocytes lacking Fc receptors, i.e., depletion of Fc receptor-bearing lymphocytes on immobolized enriches for inhibition. A T cell-enriched population does not inhibit. The effect is not steric inhibition since addition of large numbers of sheep or chicken erythrocytes does not decrease ADCC. Spontaneous cytotoxicity mediated by NK cells in the absence of added antibody is not inhibited by the FcR-depleted population, indicating that K and NK cells differ from each other in this respect.