Sudden Cardiac Death Caused by Coronary Heart Disease
Sudden Cardiac Death Caused by Coronary Heart Disease
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DOI：
10.1161/circulationaha.111.023846
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发表时间：
2012-02-28
期刊：
影响因子：
37.8
通讯作者：
Junttila, M. Juhani
中科院分区：
文献类型：
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作者：
Myerburg, Robert J.;Junttila, M. Juhani
冠状动脉粥样硬化和心脏性猝死(SCD)的解剖病理学和病理生理学之间的关系早已被认识到。在15世纪末，达芬奇描述了一种他亲眼目睹的SCD，他将其归因于“干燥、萎缩和枯萎的…”供养心脏的动脉“在尸检中，1沃伦在评论赫伯登对心绞痛的描述的意义时，报告了一名患者在出现心绞痛模式后不久突然死亡。2然而，由于冠状动脉粥样硬化的存在和程度、其潜在的血管病理生理学、心肌电生理学和缺血性心肌病的作用，对SCD的程度和机制的认识直到过去50年才开始解体。尽管随着临床、研究和介入技术的广泛进步，对急性冠脉综合征和慢性缺血性心肌病的快速性心律失常表现有了迅速发展的知识基础，尤其是在过去的25年里，预测和预防由冠心病(CHD)引起的SCD仍然是一个重要的挑战。3.
An association between the anatomic pathology and pathophysiology of coronary atherosclerosis and sudden cardiac death (SCD) has been long recognized. At the end of the 15th century, Da Vinci described a personally witnessed SCD that he attributed to a “parched and shrunk and withered… artery that feeds the heart” at autopsy, 1 and in 1812, Warren, commenting on the significance of Heberden’s description of angina pectoris, reported a patient who died suddenly a short time after presenting with an anginal pattern of chest pain. 2 However, insights into the magnitude and mechanisms of SCD as a consequence of the presence and extent of coronary atherosclerosis, its underlying vascular pathophysiology, the myocardial electrophysiology, and the role of ischemic cardiomyopathy began to unravel only during the past 50 years. Despite a rapidly developing base of knowledge about the tachyarrhythmic manifestations of acute coronary syndromes and chronic ischemic cardiomyopathy, especially during the past 25 years, that resulted from extensive clinical, investigative, and interventional advances, important challenges remain for the prediction and prevention of SCD caused by coronary heart disease (CHD). 3