Chronic administration of ketamine mimics the perturbed sense of body ownership associated with schizophrenia
Chronic administration of ketamine mimics the perturbed sense of body ownership associated with schizophrenia
复制标题
长期服用氯胺酮会模仿与精神分裂症相关的身体所有权感紊乱
DOI：
10.1007/s00213-014-3782-0
复制
发表时间：
2015
影响因子：
3.4
通讯作者：
Chen Xiaogang
中科院分区：
文献类型：
--
作者：
Tang Jinsong;Morgan Hannah L.;Liao Yanhui;Corlett Philip R.;Wang Dong;Li Hong;Tang Yanqing;Chen Jindong;Liu Tieqiao;Hao Wei;Fletcher Paul C.;Chen Xiaogang
在健康志愿者中注射亚美氯胺酮会引起早期精神病的症状，包括对自己身体的感觉变化。然而，目前尚不清楚，反复自我给药氯胺酮是否具有与急性给药时相当的对身体表现的持续影响。目的探讨慢性氯胺酮使用是否会导致身体所有权感的紊乱。方法在对急性氯胺酮输注影响的研究基础上，采用橡胶手错觉（RHI）对慢性氯胺酮服用者的身体所有权感进行了实验操纵，并与健康对照组进行了比较。结果慢性氯胺酮使用者经历了更强烈的RHI，并报告了更多的身体图像畸变，即使他们最近没有服用该药物。结论这些发现提示慢性氯胺酮治疗精神病模型的所有权意识变化更持久，可能更类似于精神分裂症。
RationaleSubanaesthetic ketamine infusion in healthy volunteers induces experiences redolent of early psychosis, including changes in the experience of one’s own body. It is not clear, however, whether repeated self-administration of ketamine has a sustained effect on body representation that is comparable to that found during acute administration.ObjectivesWe sought to establish whether chronic ketamine use resulted in disturbances to sense of body ownership.MethodsFollowing on from our work on the effects of acute ketamine infusion, we used the rubber hand illusion (RHI) to experimentally manipulate the sense of body ownership in chronic ketamine users, compared to healthy controls.ResultsChronic ketamine users experienced the RHI more strongly and reported more body-image aberrations, even though they had not recently taken the drug.ConclusionsThese findings suggest that the chronic ketamine model for psychosis models more long-lasting changes in sense of ownership, perhaps more akin to schizophrenia.