Thiol metabolism in preterm infants during the first week of life
Thiol metabolism in preterm infants during the first week of life
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DOI：
10.1080/00365510410002959
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发表时间：
2004-10-01
影响因子：
2.1
通讯作者：
Lapatto, R
中科院分区：
文献类型：
--
作者：
Ahola, T;Levonen, AL;Lapatto, R
背景：氧化应激与早产儿的几种并发症的发病机制有关。谷胱甘肽循环是细胞内最重要的抗氧化系统之一。由于半胱氨酸水平低，早产儿谷胱甘肽的合成可能不足。本研究的目的是评估早产儿出生后第一周内半胱氨酸和谷胱甘肽的代谢。研究方法：本文测定了78例出生体重500 ~ 1500 g早产儿血浆和红细胞巯基浓度，并测定了26例出生体重1000 ~ 1500 g早产儿红细胞谷氨酸-半胱氨酸连接酶（GCL）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽还原酶（GR）、谷胱甘肽S-转移酶（GST）和葡萄糖6-磷酸脱氢酶（G6 PDH）。结果：平均（SD）血浆谷胱甘肽浓度从第0天到第1天增加（14.9（7.1）vs. 27.7（11.9）mumol/L，p
Background: Oxidative stress is implicated in the pathogenesis of several complications of prematurity. The glutathione cycle is one of the most important intracellular antioxidant systems. The synthesis of glutathione may not be adequate in preterm neonates because of the low levels of cysteine available. The aim of this study was to evaluate cysteine and glutathione metabolism during the first week of life in preterm infants. Methods: Plasma and erythrocyte thiol concentrations were measured in 78 preterm infants with a birthweight of 500 1500 g, and erythrocyte glutamate-cysteine ligase (GCL), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferases (GST) and glucose 6-phosphatedehydrogenase (G6PDH) in 26 infants with a birthweight of 1000 - 1500 g. Results: The mean (SD) plasma glutathione concentration increased from day 0 to day 1 (14.9 (7.1) vs. 27.7 (11.9) mumol/L, p