Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau:: A population-based autopsy study
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau:: A population-based autopsy study
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DOI：
10.1080/07853890701842988
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Myllykangas, Liisa
中科院分区：
文献类型：
--
作者：
Tanskanen, Maarit;Peuralinna, Terhi;Myllykangas, Liisa
背景老年系统性淀粉样变性（SSA）的特征是在老年个体的实质器官中沉积基于野生型甲状腺素运载蛋白（TTR）的淀粉样蛋白。以前，没有人口为基础的研究已经进行了SSA。在此，我们研究了芬兰85岁或以上尸检人群中SSA的患病率和风险因素，作为基于人群的万塔85岁以上尸检研究（n=256）的一部分。SSA的诊断是基于刚果红染色和抗TTR免疫组织化学染色的心肌标本的组织学检查。比较9个基因的20个多态性位点在SSA患者和非SSA患者中的基因型频率。SSA的患病率为25%。SSA与年龄、心肌梗死、α 2-巨球蛋白（α 2 M）外显子24多态性的G/G（瓦尔/瓦尔）基因型和tau基因的H2单倍型相关（F值分别为0.002、0.004、0.042和0.016）。这项基于人群的研究表明，SSA在老年人中非常常见，影响了四分之一的85岁以上的人。心肌梗死和α 2 M和tau基因变异可能与SSA相关。
Background. Senile systemic amyloidosis (SSA) is characterized by deposition of wild-type transthyretin (TTR)-based amyloid in parenchymal organs in elderly individuals. Previously, no population-based studies have been performed on SSA.Methods. Here we have studied the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over, as part of the population-based Vantaa 85+ Autopsy Study (n=256). The diagnosis of SSA was based on histological examination of myocardial samples stained with Congo red and anti-TTR immunohistochemistry. The genotype frequencies of 20 polymorphisms in 9 genes in subjects with and without SSA were compared.Results. The prevalence of SSA was 25%. SSA was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (alpha 2M), and the H2 haplotype of the tau gene (F-values 0.002, 0.004, 0.042, and 0.016).Conclusion. This population-based study shows that SSA is very common in old individuals, affecting one-quarter of people aged over 85 years. Myocardial infarctions and variation in the genes for alpha 2M and tau may be associated with SSA.