Lymphangiogenesis and cancer metastasis
Lymphangiogenesis and cancer metastasis
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DOI：
10.2741/3715
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Jiang, Wen G.
中科院分区：
文献类型：
--
作者：
Al-Rawi, Mahir A. A.;Jiang, Wen G.
淋巴管生成仍然是一个令人着迷的生物过程，在正常组织发育和几种淋巴疾病中发挥着至关重要的作用。过去几年，人们对淋巴系统的发育和调节的理解取得了快速进展，这为包括癌症淋巴转移在内的多种病理过程提供了见解。淋巴管系统是肿瘤转移的主要途径。恶性细胞向区域淋巴结的播散是许多实体瘤进展的早期步骤，并且是分期和预后的重要决定因素。淋巴管生成被认为在癌细胞转移至区域淋巴结中发挥关键作用。现在认为几种人类实体瘤具有淋巴管生成性，即它们具有诱导自身淋巴管建立转移的能力。因此，通过开发抗淋巴管生成药物来靶向淋巴管生成可能是预防某些肿瘤淋巴管进展的新方法。在这里，我们回顾了淋巴系统的发育、淋巴管生成的调节，并探讨了其与几种人类癌症的关系。
Lymphangiogenesis remains a fascinating biological process that plays a crucial role in both normal tissue development and several lymphatic diseases. The last few years have witnessed a rapid progression in understanding the development and regulation of the lymphatic system which provided insight on several pathological processes including cancer lymphatic metastasis. Lymphatic vasculature serves as a major route for tumour metastasis. The dissemination of malignant cells to the regional lymph nodes is an early step in the progression of many solid tumours and is an important determinant of staging and prognosis. Lymphangiogenesis is thought to play a pivotal role for cancer cells to metastasise to the regional lymph nodes. Several human solid tumours are now considered to be lymphangiogenic i.e. they have the ability to induce their own lymphatic vessels to establish metastasis. Hence, targeting lymphangiogenesis by developing anti-lymphangiogenic agents might constitute a novel way to prevent lymphatic progression in some tumours. Here, we have reviewed the development of the lymphatic system, the regulation of lymphangiogenesis and explored its relation to several human cancers.