Preparation and physical characterization of forms II and III of paracetamol
Preparation and physical characterization of forms II and III of paracetamol
复制标题
DOI：
10.1007/bf01979491
复制
发表时间：
1997-03-01
期刊：
影响因子：
--
通讯作者：
GuyotHermann, AM
中科院分区：
文献类型：
--
作者：
DiMartino, P;Conflant, P;GuyotHermann, AM
将市售的扑热息痛晶型I熔融，得到晶型II和晶型III。在熔融和冷却条件下，可以得到晶型为I、II和III的扑热息痛。通过热显微镜、DSC分析、红外光谱分析和X射线粉末衍射等技术，研究了晶型II和晶型III的再结晶条件和物理性质。中三被发现非常不稳定。然而，它的形成似乎是准备中二的一个重要的中间步骤。
The polymorphic forms II and III of paracetamol were obtained by melting the marketed form I. Under the melting and cooling conditions used, it was possible to obtain forms I, II and III. The recrystallization conditions and the physical properties of forms II and III were investigated by means of various techniques: thermomicroscopy, DSC analysis, infrared microspectrometry and X-ray powder diffraction at room temperature and as a function of temperature. Form III was found to be very unstable. However, its formation seems to be an important intermediate step in the preparation of form II.