Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function
Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function
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DOI：
10.1038/clpt.2011.2
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发表时间：
2011-04-01
影响因子：
6.7
通讯作者：
Kim, R. B.
中科院分区：
文献类型：
--
作者：
DeGorter, M. K.;Kim, R. B.
溶质载体是膜结合蛋白的一个超家族，能够运输内源激素和结构不同的外源物质，包括临床上使用的许多药物。溶质载体促进药物进入特定的组织或器官，因此它们的抑制可能导致意外的转运介导的药物相互作用或治疗效果的丧失。溶质载体功能的小鼠模型正在为这些蛋白质的体内相关性及其对药物处置和反应的贡献提供重要的新见解。
Solute carriers represent a superfamily of membrane-bound proteins that are capable of transporting endogenous hormones as well as structurally divergent xenobiotics, including many drugs in clinical use. Solute carriers facilitate drug access to specific tissues or organs, and therefore their inhibition may result in unintended transport-mediated drug interactions or loss of therapeutic efficacy. Mouse models of solute carrier function are providing important new insights into the in vivo relevance of these proteins and their contribution to drug disposition and response.