Neural control properties of the external anal sphincter in young and elderly women.
Neural control properties of the external anal sphincter in young and elderly women.
复制标题
年轻和老年女性肛门外括约肌的神经控制特性。
DOI：
10.1002/nau.24108
复制
发表时间：
2019
影响因子：
2
通讯作者：
Zhang,Yingchun
中科院分区：
文献类型：
--
作者：
Dias,Nicholas;Zhang,Chuan;Li,Xuhong;Neshatian,Leila;Orejuela,FranciscoJ;Zhang,Yingchun
目的大便失禁（FI）的患病率随着年龄的增长而增加，并影响超过15%的老年人口。肌肉减少症，骨骼肌结构和功能随着年龄的增长而下降，已知是由神经肌肉功能障碍引起的。然而，尚未研究肛门外括约肌（EAS）神经肌肉功能的年龄相关变化。本研究旨在通过使用高密度表面肌电图（HD-sEMG）记录和分析技术评估运动单位动作电位（MUAP）的放电模式和大小来定量表征衰老对EAS的影响。通过64通道HD sEMG直肠内探头记录EAS在最大自主收缩期间的EMG活动。将HD‐sEMG信号分解为MUAP锋电位序列，提取放电频率和幅值。对于年轻组和老年组，获得的平均运动单位（MU）放电率分别为11.4 ± 2.1脉冲每秒（PPS）和9.6 ± 2.3 PPS，平均MUAP振幅分别为45.2 ± 14.3 µV和61.9 ± 21.2 µV。两组间MU放电频率和MUAP振幅差异均有统计学意义（P<0.05）。此外，MUAP的放电率和振幅与年龄相关的线性回归模型（P< .05）。结论这项研究是第一次努力检查的影响，年龄对EAS的神经肌肉功能。结果表明，下运动神经元对EAS的下行兴奋存在年龄相关性损伤，平均MU大小代偿性增加。
AimsThe prevalence of fecal incontinence (FI) increases with age and affects more than 15% of the elderly population. Sarcopenia, skeletal muscle structural, and functional decline with aging, is known to be caused by neuromuscular dysfunction. However, age‐related alterations of the neuromuscular function of the external anal sphincter (EAS) have not been studied. This study aims to quantitatively characterize the effect of aging on the EAS by assessing the firing patterns and size of motor unit action potential (MUAP) using high‐density surface electromyography (HD‐sEMG) recording and analysis techniques.MethodsThirteen young (31.0 ± 3.6 years) and 14 elderly (64.3 ± 6.2 years) healthy women were recruited for this study. EMG activity of the EAS during maximal voluntary contraction was recorded by a 64‐Channel, HD‐sEMG intra‐rectal probe. HD‐sEMG signals were decomposed into MUAP spike trains to extract the firing rate and amplitudes thereof.ResultsHD‐sEMG decomposition was successfully performed. For the young and elderly groups, mean motor unit (MU) firing rates of 11.4 ± 2.1 pulses per second (PPS) and 9.6 ± 2.3 PPS, and mean MUAP amplitudes of 45.2 ± 14.3 µV and 61.9 ± 21.2 µV were respectively obtained. Both the MU firing rate and MUAP amplitude were significantly different between two groups (P< .05). Moreover, the MUAP firing rate and amplitude correlated with age with a linear regression model (P< .05).ConclusionsThis study represents the first effort to examine the effect of aging on the neuromuscular function of EAS. Results suggest an age‐related impairment of lower motor neuron descending excitation to the EAS with a compensatory increase in mean MU size.