APOMORPHINE-INDUCED STEREOTYPED BITING IN TORTOISE IN RELATION TO DOPAMINERGIC MECHANISMS
APOMORPHINE-INDUCED STEREOTYPED BITING IN TORTOISE IN RELATION TO DOPAMINERGIC MECHANISMS
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DOI：
10.1159/000123646
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发表时间：
1975-01-01
影响因子：
1.7
通讯作者：
RANDRUP, A
中科院分区：
文献类型：
--
作者：
ANDERSEN, H;BRAESTRUP, C;RANDRUP, A
描述了摩洛哥池龟(Clemmys Caspica Leprosa)在服用阿朴吗啡后的咬伤行为。特异性抗多巴胺能药物氟哌啶醇(10 mg/kg)和三氟哌嗪(15 mg/kg)可拮抗咬人行为。这一行为与鸟类和哺乳动物的类似行为进行了比较。用气相色谱方法测定了龟脑中的多巴胺代谢产物高香草酸和3，4-二羟基苯乙酸。从给药对行为的影响和这些代谢物水平的变化可以得出结论，乌龟体内的多巴胺系统与鸟类和哺乳动物的多巴胺系统性质相似，但对阻滞剂的敏感性较低。
A biting behavior in the Moroccan pond tortoise(Clemmys caspica leprosa)after apomorphine administration is described. The biting behavior was antagonized by the specific anti-dopaminergic drug haloperidol (10 mg/kg) and trifluperazine (15 mg/kg). The behavior was compared to similar behaviors in birds and mammals. The dopamine metabolites, homovanillic acid and 3,4-dihydroxyphenylacetic acid, were measured by a gas chromatographic method in the tortoise brain. From the effects on behavior and the changes in the level of these metabolites upon drug administration it was concluded that the dopamine system in the tortoise is qualitatively similar to that in birds and mammals but less sensitive to blockade.