Host entry by gamma-herpesviruses - lessons from animal viruses?
Host entry by gamma-herpesviruses - lessons from animal viruses?
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DOI：
10.1016/j.coviro.2015.07.007
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发表时间：
2015-12-01
影响因子：
5.9
通讯作者：
Stevenson, Philip G.
中科院分区：
文献类型：
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作者：
Gillet, Laurent;Frederico, Bruno;Stevenson, Philip G.
The oncogenicity of gamma-herpesviruses (gamma HVs) motivates efforts to control them and their persistence makes early events key targets for intervention. Human gamma HVs are often assumed to enter naive hosts orally and infect B cells directly. However, neither assumption is supported by direct evidence, and vaccination with the Epstein-Barr virus (EBV) gp350, to block virion binding to B cells, failed to reduce infection rates. Thus, there is a need to re-evaluate assumptions about, gamma HV host entry. Given the difficulty of analysing early human infections, potentially much can be learned from animal models. Genomic comparisons argue that gamma HVs colonized mammals long before humans speciation, and so that human gamma HVs are unlikely to differ dramatically in behaviour from those of other mammals. Murid Herpesvirus-4 (MuHV-4), which like EBV and the Kaposi's Sarcoma-associated Herpesvirus (KSHV) persists in memory B cells, enters new hosts via olfactory neurons and exploits myeloid cells to spread. Integrating these data with existing knowledge of human and veterinary gamma HVs suggests a new model of host entry, with potentially important implications for infection control.
