Dipalmitoylphosphatidylcholine (DPPC) and DPPC/cholesterol liposomes as predictors of the cytotoxicity of Bis-GMA related compounds
Dipalmitoylphosphatidylcholine (DPPC) and DPPC/cholesterol liposomes as predictors of the cytotoxicity of Bis-GMA related compounds
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DOI：
10.1081/lpr-120039662
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发表时间：
2004-01-01
影响因子：
4.4
通讯作者：
Yokoe, I
中科院分区：
文献类型：
--
作者：
Fujisawa, S;Kadoma, Y;Yokoe, I
根据最近的发展，牙科材料如2，2-双[4-2（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]丙烷，（双-GMA）; 2，2-双[4-甲基丙烯酰氧基丙氧基]苯基]丙烷，（1-羟甲基-2-甲基丙烯酰氧基）苯基]丙烷，（异-双-GMA）;和三甘醇二甲基丙烯酸酯（TEGDMA）进行了研究，以确定它们的相变性能用差示扫描量热法（DSC）测定了DPPC或DPPC/胆固醇（CHOL）脂质体的相变温度、相变温度宽度、相变协同性。TEGDMA对DPPC脂质体相变性质的影响大于bis-GMA和iso-bis-GMA，但对DPPC/CHOL（10：1或4：1）脂质体相变性质的影响程度依次为bis-GMA > iso-bis-GMA > TEGDMA。改变的程度与这些化合物的细胞毒性有关。发现DPPC/CHOL脂质体比DPPC脂质体更好地预测细胞毒性。是否计算的方法来研究的分子机制的改变是适用的使用描述符，如最高占据分子轨道（HOMO）和/或最低未占分子轨道（LUMO）的能量反应性进行了调查，数据表明，这些描述符是有用的研究牙科材料的相互作用。
In light of recent development, dental materials such as 2, 2-bis [4-2(-hydroxy-3-methacryloyloxypropoxy)phenyl] propane, (bis-GMA); 2, 2-bis [4-(1-hydroxymethyl-2-methacryloxy)phenyl] propane, (iso-bis-GMA); and triethyleneglycol dimethacrylate, (TEGDMA) were investigated to determine whether their phase transition properties (phase transition temperature, temperature width, cooperativity) could be induced in samples of DPPC or DPPC/cholesterol (CHOL) liposomes using differential scanning calorimetry (DSC). The changes in phase transition properties of DPPC liposomes caused by addition of TEGDMA were greater than those caused by addition of bis-GMA or iso-bis-GMA, but the extent of changes in the properties of DPPC/CHOL (10:1 or 4:1) liposomes declined in the order of bis-GMA > iso-bis-GMA > TEGDMA. The degree of alteration was related to the cytotoxicity of these compounds. DPPC/CHOL liposomes were found to be better predictors of cytotoxicity than DPPC liposomes. Whether the computational approach to studying the molecular mechanism of alteration is applicable using descriptors such as reactivity of energy of the highest occupied molecular orbital (HOMO) and/or lowest unoccupied molecular orbital (LUMO) was investigated, and the data suggested that these descriptors are useful for studying the interactive roles of dental materials.