Waist Circumference and Domain-Specific Cognitive Function Among Non-Demented Japanese Older Adults Stratified by Sex: Results from the Takashima Cognition Study.
Waist Circumference and Domain-Specific Cognitive Function Among Non-Demented Japanese Older Adults Stratified by Sex: Results from the Takashima Cognition Study.
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DOI：
10.3233/jad-190395
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Dodge HH
中科院分区：
文献类型：
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作者：
Waki T;Tanaka-Mizuno S;Takashima N;Takechi H;Hayakawa T;Miura K;Ueshima H;Kita Y;Dodge HH
虽然中年肥胖与晚年痴呆和认知能力下降的风险增加有关，但一些研究表明，晚年肥胖与这些结果的风险较低有关。这种现象被称为“肥胖悖论”，但其根本原因和潜在的性别差异尚未得到充分了解。旨在分别研究每一代晚年老年人中男性和女性的认知与腰围（WC）之间的关联，腰围是身体脂肪的替代测量方法，比体重指数（BMI）更容易测量。本研究使用了 335 名参与者，他们是在 2005 年至 2006 年期间对日本滋贺县高岛县 65-74 岁、75-84 岁和 85 岁以上的居民进行随机抽样确定的。使用具有年龄、教育程度和高血压等协变量的多变量线性回归模型检查了 WC 与通过 12 项神经心理学测试测量的特定领域认知功能之间的关联。较大的 WC 与 65-74 岁女性更好的注意力/工作记忆相关，与 65-74 岁男性更好的学习/习得相关，而较大的 WC 与 75-84 岁男性的学习/习得、记忆、注意力/工作记忆和语言/流畅性较差相关。我们发现 WC 与特定领域认知功能之间的关联存在年龄和性别差异。在老年男性（75-84岁）中，较大的腰围对记忆、注意力、语言和执行功能等多个领域都有负面影响，而我们没有发现较大的腰围对任何年龄段女性的认知有任何负面影响。
While being obese in mid-life is associated with an increased risk of dementia and cognitive decline in late-life, being obese in late-life is shown to be associated with a lower risk of these outcomes in some studies. This phenomenon is known as the “obesity paradox”, but the underlying reasons and potential sex difference have not been well understood. To investigate the association between cognition and waist circumference (WC), an alternative measure of body fat which can be measured easier than body mass index (BMI), among older adults in each generation of late-life for men and women separately. Three hundred thirty-five participants were used in the current study who were identified by random sampling of residents aged 65–74, 75–84, and 85+years in Takashima County, Shiga Prefecture, Japan during 2005–2006. Associations between WC and domain-specific cognitive functions measured by 12 neuropsychological tests were examined using multivariable linear regression models with covariates: age, education, and hypertension. Larger WC was associated with better attention/working memory among 65–74-year old women and with better learning/acquisition among 65–74-year-old men, while larger WC was associated with worse learning/acquisition, memory, attention/working memory, and language/fluency among 75–84-year old men. We found age and sex differences in the association between WC and domain-specific cognitive functions. Among older old men (age 75–84), larger WC had negative effects on various domains including memory, attention, language, and executive functions, while we did not find any negative effects of larger WC on cognition among women in any age groups.