Prinzmetal's variant angina. Coronary arteriogram and left ventriculogram during angina attack induced by methacholine.
Prinzmetal's variant angina. Coronary arteriogram and left ventriculogram during angina attack induced by methacholine.
复制标题
Prinzmetal 的变异性心绞痛。
DOI：
--
复制
发表时间：
1976
影响因子：
158.5
通讯作者：
Soji Konno
中科院分区：
文献类型：
--
作者：
Masahiro Endo;Koshichiro Hirosawa;Noboru Kaneko;Kasuo Hase;Yasuo Inoue;Soji Konno
最近，在普林兹金属变异型心绞痛中，有许多冠状动脉正常的病例报道。冠状动脉搭桥术后心绞痛发作频繁复发。类似副交感神经的药物，如乙酰甲胆碱和匹罗卡品，常常可能诱发心绞痛发作。本研究对3例心绞痛患者皮下注射乙酰甲胆碱(0.13 mg/kg)诱发心绞痛发作，并记录冠脉造影和左心室造影。所有病例均可观察到与心电图ST段抬高部位相对应的冠状动脉痉挛。即使在正常冠状动脉，也能观察到由于痉挛而导致的完全闭塞。与心电图ST段抬高部位相对应的左室壁可见协同效应。
Recently, in Prinzmetal's variant angina, many cases with normal coronary arteries have been reported. The anginal attacks frequently relapse after aortocoronary bypass grafting. It is frequently possible to induce an anginal attack by parasympathomimetic agents such as methacholine and pilocarpine. In this study, methacholine (0.13 mg per kilogram) was injected subcutaneously in three cases of this disease to induce an angina attack, and coronary arteriograms and left ventriculograms were recorded. In all cases a coronary arterial spasm corresponding to the site of the ST-segment elevation in the electrocardiogram was observed. Complete occlusion due to the spasm was observed even in the normal coronary artery. Asynergy was seen in the left ventricular wall corresponding to the site of the ST-segment elevation in the electrocardiogram.