Activation of mosquito immunity blocks the development of transmission-stage filarial nematodes
Activation of mosquito immunity blocks the development of transmission-stage filarial nematodes
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DOI：
10.1073/pnas.1909369117
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发表时间：
2020-02-18
影响因子：
11.1
通讯作者：
Povelones, Michael
中科院分区：
文献类型：
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作者：
Edgerton, Elizabeth B.;McCrea, Abigail R.;Povelones, Michael
蚊媒蠕虫感染对全球人类和动物造成重大疾病负担。因此，开发新策略以通过针对载体中的这些病原体来减少疾病传播至关重要。我们发现，一种对犬心丝虫病病原体恶丝虫（Dirofilaria immitis）感染具有抵抗力的埃及伊蚊菌株，在感染过程中比易感菌株产生更强的免疫反应。此外，易感菌株中Toll免疫信号通路的激活会阻止寄生虫幼虫的发育，从而减少传播阶段幼虫的数量。值得注意的是，这一策略还可以阻断传播阶段的马来丝虫（人类淋巴丝虫病的一种病原体）。我们的数据表明，蚊子免疫力在限制丝虫线虫发育方面可以发挥关键作用，并表明具有增强免疫力的基因工程蚊子将有助于减少病原体传播。
Mosquito-borne helminth infections are responsible for a significant worldwide disease burden in both humans and animals. Accordingly, development of novel strategies to reduce disease transmission by targeting these pathogens in the vector are of paramount importance. We found that a strain of Aedes aegypti that is refractory to infection by Dirofilaria immitis, the agent of canine heartworm disease, mounts a stronger immune response during infection than does a susceptible strain. Moreover, activation of the Toll immune signaling pathway in the susceptible strain arrests larval development of the parasite, thereby decreasing the number of transmission-stage larvae. Notably, this strategy also blocks transmission-stage Brugia malayi, an agent of human lymphatic filariasis. Our data show that mosquito immunity can play a pivotal role in restricting filarial nematode development and suggest that genetically engineering mosquitoes with enhanced immunity will help reduce pathogen transmission.