Side and type of initial motor symptom influences visuospatial functioning in Parkinson's disease.
Side and type of initial motor symptom influences visuospatial functioning in Parkinson's disease.
复制标题
DOI：
10.3233/jpd-140365
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Cronin-Golomb A
中科院分区：
文献类型：
--
作者：
Seichepine DR;Neargarder S;Davidsdottir S;Reynolds GO;Cronin-Golomb A
视觉空间问题在帕金森病（PD）中很常见，可能源于多巴胺能通路功能障碍和随之而来的皮质功能中断。表征疾病发作时的运动症状提供了观察这些通路中的功能障碍如何影响视觉空间认知的方法。我们检查了两种类型的运动特征：体侧（左侧或右侧）和初始症状类型（震颤或震颤以外的症状）。31例非痴呆PD患者，16例左侧发作（LPD）和15例右侧发作（RPD），以及17例健康对照参与者（HC）。PD组还按初始运动症状的类型进行了划分，15例以震颤为初始症状，16例以震颤以外的其他初始症状。视觉空间功能采用画钟测验进行评估。在使用的四种时钟绘制评分方法中，Rouleau方法对亚组差异表现出敏感性。正如预测的那样，LPD和非震颤亚组，而不是其他亚组，比HC组表现更差。这些发现为这些PD亚型之间的认知差异提供了进一步的证据，并强调了在检查认知时考虑疾病亚型的重要性。
Visuospatial problems are common in Parkinson’s disease (PD) and likely stem from dysfunction in dopaminergic pathways and consequent disruption of cortical functioning. Characterizing the motor symptoms at disease onset provides a method of observing how dysfunction in these pathways influences visuospatial cognition. We examined two types of motor characteristics: body side (left or right) and type of initial symptom (tremor or symptom other than tremor). 31 non-demented patients with PD, 16 with left-side onset (LPD) and 15 with right-side onset (RPD), as well as 17 healthy control participants (HC). The PD group was also divided by type of initial motor symptom, 15 having tremor as the initial symptom and 16 having an initial symptom other than tremor. Visuospatial function was assessed with the Clock Drawing Test. Of the four Clock Drawing scoring methods used, the Rouleau method showed sensitivity to subgroup differences. As predicted, the LPD and non-tremor subgroups, but not the other subgroups, performed more poorly than the HC group. The findings provide further evidence for differences in cognition between these subtypes of PD and highlight the importance of considering disease subtypes when examining cognition.