The Biological Treatment of Paraphilic Disorders: an Updated Review
The Biological Treatment of Paraphilic Disorders: an Updated Review
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性欲倒错疾病的生物治疗：最新综述
DOI：
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发表时间：
2016
影响因子：
6.7
通讯作者：
Denise C. Kellaher
中科院分区：
文献类型：
--
作者：
B. Holoyda;Denise C. Kellaher
反性癖障碍的特征是不典型的性兴趣、性幻想和行为，这些行为主观上给患者带来痛苦或对他人造成伤害的风险。就其本质而言，某些反性恋障碍可能使个体容易犯下性犯罪。因此，对于精神病学和整个社会来说，对性反常障碍的生物学治疗是至关重要的。三种常用的治疗嗜旁性疾病的药物是选择性血清素再摄取抑制剂、合成类固醇类似物和促性腺激素释放激素类似物。每种药物使用不同的作用机制，对性反常障碍的生理和心理特征有不同的影响。总的来说，支持这些药物使用的高质量研究有限。尽管如此，一些作者提出了不同严重程度的反性恋障碍个体的治疗算法。这些指南为临床医生提供了潜在有用的、合理的方法来评估嗜性反倾症患者的治疗需求。最近的神经成像研究表明，功能性磁共振成像可能会为有效评估性反常障碍提供进一步的希望，以帮助指导治疗方案。
Paraphilic disorders are characterized by atypical sexual interests, fantasies, and behaviors that are subjectively distressing to patients or pose a risk of harm to others. By their very nature, some paraphilic disorders may predispose an individual to commit sexual offenses. The biological treatment of paraphilic disorders, then, is of paramount importance for psychiatry and society at large. Three categories of pharmacologic agents commonly used to treat paraphilic disorders are selective serotonin reuptake inhibitors, synthetic steroidal analogs, and gonadotropin-releasing hormone analogs. Each medication uses a different mechanism of action and has different effects on the physiological and psychological features of paraphilic disorders. In general, these medications have limited high-quality research to support their use. Despite this, some authors have proposed treatment algorithms for individuals with paraphilic disorders of varying severity. These guidelines offer clinicians potentially useful, rational approaches to assessing treatment need in individuals with paraphilic disorders. Recent neuroimaging research suggests that functional magnetic resonance imaging may offer further promise in effectively assessing paraphilic disorders to help direct treatment options.
促性腺激素释放激素及其类似物。
DOI：
10.1056/nejm199101103240205
发表时间：
1991
期刊：
The New England journal of medicine
影响因子：
--
作者：
Conn,PM;CrowleyJr,WF
通讯作者：
CrowleyJr,WF