A central arteriovenous fistula reduces systemic hypertension in a mouse model.
A central arteriovenous fistula reduces systemic hypertension in a mouse model.
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中央动静脉瘘可降低小鼠模型的全身性高血压。
DOI：
10.1016/j.jvssci.2024.100191
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Dardik,Alan
中科院分区：
文献类型：
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作者：
Brahmandam,Anand;Alves,Rafael;Liu,Hao;Gonzalez,Luis;Aoyagi,Yukihiko;Ohashi,Yuichi;Langford,JohnT;Thaxton,Carly;Taniguchi,Ryosuke;Zhang,Weichang;Bai,Hualong;Yatsula,Bogdan;Dardik,Alan
中心动静脉内瘘（AVF）已被提出作为治疗难治性高血压患者的潜在新解决方案。我们假设在高血压环境中AVF建立后的静脉重构降低了全身血压，但与正常血压环境中的重构相比，AVF壁厚度增加。结果单独应用Ang Ⅱ组，术后第21天平均收缩压由90 ± 5 mmHg升高至160 ± 5 mmHg;然而，在用Ang II和AVF处理的小鼠中，血压随着AVF的产生而降低。有显着更多的PCNA阳性细胞，SM 22 α/PCNA阳性细胞，I型胶原沉积，并增加Krüppel样因子2免疫反应性高血压小鼠AVF与AVF.ConclusionsThese数据表明，中央AVF降低全身性高血压，以及诱导局部改变静脉重塑。
ObjectiveA central arteriovenous fistula (AVF) has been proposed as a potential novel solution to treat patients with refractory hypertension. We hypothesized that venous remodeling after AVF creation in the hypertensive environment reduces systemic blood pressure but results in increased AVF wall thickness compared with remodeling in the normotensive environment.MethodsA central AVF was performed in C57BL6/J mice previously made hypertensive with angiotensin II (Ang II); mice were sacrificed on postoperative day 7 or 21.ResultsIn mice treated with Ang II alone, the mean systolic blood pressure increased from 90 ± 5 mmHg to 160 ± 5 mmHg at day 21; however, in mice treated with both Ang II and an AVF, the blood pressure decreased with creation of an AVF. There were significantly more PCNA-positive cells, SM22α/PCNA-positive cells, collagen I deposition, and increased Krüppel-like Factor 2 immunoreactivity in hypertensive mice with an AVF compared with normotensive mice with an AVF.ConclusionsThese data show that a central AVF decreases systemic hypertension as well as induces local alterations in venous remodeling.