Peripapillary Retinal Nerve Fiber Layer Swelling Predicts Peripapillary Atrophy in a Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy.
Peripapillary Retinal Nerve Fiber Layer Swelling Predicts Peripapillary Atrophy in a Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy.
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DOI：
10.1167/iovs.15-17880
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发表时间：
2016-02
影响因子：
4.4
通讯作者：
Bernstein SL
中科院分区：
文献类型：
--
作者：
Johnson MA;Miller NR;Nolan T;Bernstein SL
在非动脉炎性前部缺血性视神经病变（pNAION）的非人灵长类动物模型中，确定视乳头周围视网膜神经纤维层（PRNFL）肿胀与最终PRNFL萎缩之间的关系，以及PRNFL肿胀/萎缩与神经功能之间的关系。通过激光激活视神经乳头静脉注射虎红，在5只正常成年雄性恒河猴中诱导pNAION。在基线、1天、1周、2周和4周以及随后2至3个月的几次时间点进行PRNFL的光谱域光学相干断层扫描测量。同时记录图形反转视网膜电图（PERG）和视觉诱发电位（VEP），并在相同时间点拍摄彩色眼底照片。在所有病例中，初始PRFL肿胀与萎缩相关，初始肿胀越大，最终萎缩的程度越大（r = 0.65，P = 0.0002）。PRNFL厚度的变化与VEP振幅损失密切相关（r = 0.90），尽管这种关系只是一个强趋势（P = 0.083）。此外，VEP振幅损失与PERG N95振幅损失密切相关（r = 0.80，P = 0.00002）。在我们的人NAION模型中，初始PRNFL肿胀程度与萎缩严重程度相关。没有肿胀的区域几乎没有萎缩。PRNFL损失的金额反映在VEP和PERG N95振幅的降低中。
To determine the relationship between peripapillary retinal nerve fiber layer (PRNFL) swelling and eventual PRNFL atrophy, and between PRNFL swelling/atrophy and neural function, in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy (pNAION). pNAION was induced in five normal, adult male rhesus monkeys by laser activation of intravenously injected rose bengal at the optic nerve head. Spectral-domain optical coherence tomography measurements of the PRNFL were performed at baseline; 1 day; 1, 2, and 4 weeks; and several later times over a period of an additional 2 to 3 months. Simultaneous pattern-reversal electroretinograms (PERGs) and visual evoked potentials (VEPs) were recorded and color fundus photographs taken at the same time points. In all cases, initial PRNFL swelling was associated with atrophy, and the greater the initial swelling, the greater the degree of eventual atrophy (r = 0.65, P = 0.0002). The change in PRNFL thickness closely correlated with VEP amplitude loss (r = 0.90), although this relationship was only a strong trend (P = 0.083). Furthermore, VEP amplitude loss closely correlated with PERG N95 amplitude loss (r = 0.80, P = 0.00002) In our model of human NAION, the degree of initial PRNFL swelling correlated with the severity of atrophy. Areas that did not swell developed little to no atrophy. The amount of PRNFL loss was reflected in VEP and PERG N95 amplitude reductions.