Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT
Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT
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DOI：
10.1007/s00259-009-1152-7
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发表时间：
2009-10-01
影响因子：
9.1
通讯作者：
Stegger, Lars
中科院分区：
文献类型：
--
作者：
Kato, Katsuhiko;Schober, Otmar;Stegger, Lars
目的炎症性动脉粥样硬化斑块可破裂并引起急性心肌梗死、脑卒中等血栓性事件。在许多情况下，早期发现这些不稳定的斑块可以预防这种潜在的致命事件。用于可视化磷脂合成的C-11-胆碱或F-18-标记的胆碱衍生物是有希望的斑块炎症标记物，具有优于F-18-FDG的潜在优势。然而，它们在人类斑块表征中的潜力尚不清楚。在这项研究中，结合PET/CT评估了老年男性患者主动脉和颈总动脉壁中C-11-胆碱摄取的患病率和分布。此外，放射性示踪剂的摄取和钙化的本地化相关的各种vessel segment.Methods图像数据从93个连续的男性患者之间的60和80岁谁经历了全身C-11-胆碱PET/CT评估前列腺癌进行了回顾性评价。结果95%的患者血管段内有C-11-胆碱摄取，94%的患者血管段内有钙化。在6%的患者放射性示踪剂摄取与钙化共定位，而不到1%的钙化部位表现出增加放射性示踪剂uptake.Conclusions无论是C-11-胆碱摄取和钙化的主动脉和颈总动脉壁是常见的老年男性。然而，放射性示踪剂摄取和钙化很少共存。C-11-胆碱有可能提供不依赖于钙化测量的动脉粥样硬化斑块的信息。
Purpose Inflamed atherosclerotic plaques may rupture and cause acute myocardial infarction, stroke and other thrombotic events. Early detection of these unstable plaques could, in many cases, prevent such potentially fatal events. C-11-choline or F-18-labelled choline derivatives for visualizing the synthesis of phospholipids, are promising markers of plaque inflammation with potential advantages over F-18-FDG. Their potential for plaque characterization in humans is, however, unclear. In this study the prevalence and distribution of C-11-choline uptake in the aortic and common carotid arterial walls of elderly male patients was evaluated with combined PET/CT. Additionally, the localization of radiotracer uptake and calcification was correlated in various vessel segments.Methods Image data from 93 consecutive male patients between 60 and 80 years old who had undergone whole-body C-11-choline PET/CT assessment for prostate cancer were evaluated retrospectively. C-11-choline uptake and calcification were analysed qualitatively and semiquantitatively and compared.Results C-11-choline uptake was found in 95% of patients, calcification in 94% throughout all vessel segments. In 6% of the patients radiotracer uptake was colocalized with calcifications, whereas less than 1% of calcification sites showed increased radiotracer uptake.Conclusion Both C-11-choline uptake and calcification in the aortic and common carotid arterial walls are common in elderly men. Radiotracer uptake and calcification are, however, only rarely colocalized. C-11-choline has the potential to provide information about atherosclerotic plaques independent of calcification measurement.