Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia
Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia
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DOI：
10.1080/15622970903144004
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发表时间：
2009-01-01
影响因子：
3.1
通讯作者：
Dalkilic, Alican
中科院分区：
文献类型：
--
作者：
Bulut, Mahmut;Savas, Haluk Asuman;Dalkilic, Alican
抗精神病药物疗效不佳仍然是许多精神分裂症患者治疗中的一个重要问题。N-乙酰半胱氨酸（NAC）是一种对活性氧具有抗氧化和清除作用的化合物。本文报告一例反应不良的精神分裂症患者，加用NAC 600 mg/d后，病情明显改善。NAC可能通过激活半胱氨酸-谷氨酸反向转运蛋白或减少一氧化氮（NO）代谢产物、自由基和细胞因子或通过这两种机制发挥作用。
Poor response to antipsychotics is still an important problem in the treatment of many schizophrenia patients. N-Acetylcysteine (NAC) is a compound that exerts anti-oxidant and scavenging actions against reactive oxygen species. This paper reports a case of poorly responsive schizophrenia patient who improved considerably with add-on NAC 600 mg/day. The NAC might work through activating cysteine-glutamate antiporters or reducing in nitric oxide (NO) metabolites, free radicals and cytokines or through both of these mechanisms.